... A201A biosyn-thetic pathway, may be related to their counterparts of < /b> the< /b> puromycin and hygromycin A biosynthetic pathways,respectively. The < /b> puromycin biosynthetic gene cluster (pur)fromS. alboniger ... shown)[33,34]. In contrast, its similarity to type III PKSs, whichlack this domain, is scant. This domain promotes the< /b> binding < /b> of < /b> the < /b> acyl-CoA initiation unit to the < /b> ketosynthetasedomain of < /b> the < /b> PKSs ... Jime´nez, A. (1985) Biosynthesis of < /b> puromycin by Streptomyces alboniger: characterization of< /b> puromycin N-acetyltransferase. Biochemistry 24, 8074–8081.22. Muth,G.,Nubbaumer ,B. ,Wohlleben,W.&Pu¨hler,...