... 5529–5534.9 Qiu L, Joazeiro C, Fang N, Wang HY, Elly C, AltmanY, Fang D, Hunter T & Liu YC (2000) Recognition and ubiquitination of Notch by Itch, a hect-type E3ubiquitin ligase. J Biol Chem 275, ... guiding intracellular localization tointernal membranes, four WW domains involved insubstrate recognition and a C-terminal catalyticdomain [1]. Itch is best known for its role in immunesystem...