... Subbuswamy K. Prabu1,*, Cynthia M. Otto2and Narayan G. Avadhani11Department of Animal Biology and2Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania,Philadelphia, ... There was a generalized decline in mitochondrial function that led to a decrease in total cellularheme and ATP pools. We also observed a decrease in mitochondrial heme aa3content and decreased ... requires a high concentration of ATP (0.5–1 mM) for maximal activity. Narasimhanand Attardi [41] showed that a high concentration of 5¢-adenylylimidodiphosphate was able to stimulate theTable...