... A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins Christopher D. Syme1, Ewan W. Blanch1, ... similar to those in the a- synucleins. These data suggest that, as in the caseins, the majorconformational element present in wild-type a- synuclein and the A3 0P and A5 3T mutants, as well as in b -and c-synu ... DSC, of caseins, synucleins and tau, togetherwith several mutants of a- synuclein and tau that causeneurodegenerative diseases. The ROA spectra of all these proteins are very similar to those of...