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Tài liệu Báo cáo khoa học: Domain IV of mouse laminin b1 and b2 chains Structure, glycosaminoglycan modi®cation and immunochemical analysis of tissue contents pptx

Tài liệu Báo cáo khoa học: Domain IV of mouse laminin b1 and b2 chains Structure, glycosaminoglycan modi®cation and immunochemical analysis of tissue contents pptx

Tài liệu Báo cáo khoa học: Domain IV of mouse laminin b1 and b2 chains Structure, glycosaminoglycan modi®cation and immunochemical analysis of tissue contents pptx

... al.(Eur. J. Biochem. 269) Ó FEBS 2002 Domain IV of mouse laminin b1 and b2 chains Structure, glycosaminoglycan modi®cation and immunochemical analysis of tissue contents Takako Sasaki1, Karlheinz ... were all negative.RESULTSExpression and puri®cation of recombinant domain IV from mouse laminin b1 and b2 chain Domain IV of t he b1 (position 541±771) and b2 (position556±782) chains correspond ... 0.1±0.2 nMb 1IV and b 2IV, respectively (Fig. 5). The b 1IV assay was inhibited in nearlyidentical manner by m onomeric and dimeric b 1IV and theproteoglycan form and by laminin- 1 (a1b1c1) derived fromthe...
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Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc

Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc

... categorized and des-cribed misannotations of domains to discern themfrom real substitutions or deletions of domains. Next,we studied whether some domains are more often lost and whether frequencies of ... 10 and 11 domains. Dark grey, Pfam; Light grey, ProDom.Length of the deleted fragment (in domains) Number of occurenciesFig. 2. Number of occurrences of domain deletions as a function of the ... (2004) Structure, function and evolution of multidomain proteins. Curr Opin Struct Biol 14, 208–216.21 Kummerfeld S & Teichmann S (2005) Relative rates of gene fusion and fission in multi-domain...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Domain-Independent Natural Language Database Access Systems" pptx

... narrow domain (i.e., content area) and relying heavily on domain- speci- fic knowledge to guide the language understanding process. Transporting a system constructed for one domain into a new domain ... referent of "their = in (13) would not be perceived as having an adequate cos- sand of the English language and the same would be true for a computer system that did not understand the ... at best only a shallow level of understanding and one that does not meet the criterion specifled above. Further, the domain- independent approach creates a host of problems that are simply non-ex-...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Domain-transcending mappings in a system for metaphorical reasoning" docx

... the domain of vehicles and journeys) to thetarget domain (the domain of the lovers and theirrelationship). Yet the mapping of this emotionalstate seems to be a key part of the meaning of themetaphor, ... context of the target. Also,qualitative duration comparisons map over.Rate VNMA: Qualitative rate of progress of anevent in the source domain maps identically toqualitative rate of progress of ... Qualitative size (relative orabsolute) of sets in the source domain mapsidentically to qualitative size of mappee sets inthe target domain. E.g., if a set is large in theterms of the source domain...
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Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx

Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx

... cells,neutrophils, and eccrine glands [13]. Cathelicidins killGram-positive and Gram-negative bacteria and Trypanosoma cruzi. Similar to defensins, cathelicidinsparticipate actively in linking innate and ... antibacterial activity againstGram-negative bacteria and some fungi, whereashBD3 has a broader spectrum and kills many patho-genic Gram-positive and Gram-negative bacteria and opportunistic ... production of proinflammatory cytokines, to pro-mote the recruitment of dendritic cells and monocytesto the site of injury, and to enhance phagocytosis and the maturation of dendritic cells. All of...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf

Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf

... member of the ErbB family, is important in the regulation of growth, differentiation and survival of various celltypes. Ligand binding to EGFR results in receptordimerization, activation of its ... thatblockage of the EGFR activity with gefitinib is ableto cause suppression of a downstream signalingpathway through Ras-MAPK and or PtdIns3K ⁄ Akt, and induce apoptosis through activation of thepro-apoptotic ... by exposure of cells to a variety of stresses [19–21]. JNK activity hasbeen implicated in both apoptosis and survival signal-ing and is tightly controlled by both protein kinases and protein...
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Tài liệu Báo cáo khoa học: FOXM1c transactivates the human c-mycpromoter directly via the two TATA boxes P1 and P2 docx

Tài liệu Báo cáo khoa học: FOXM1c transactivates the human c-mycpromoter directly via the two TATA boxes P1 and P2 docx

... immune and endocrine systems, components of signaling pathways and of the ubiquitin–proteasomepathway, and genes of tumor viruses. Activation of cell-cycle regulators, proto-oncogenes and genesinvolved ... not transactivated byFOXM1c(189–762) (Fig. 1C).The P1 and P2 TATA boxes are theFOXM1c-responsive elementsThe existence of FOXM1c-responsive and -nonrespon-sive minimal promoters offered the ... transactivation; IA, interaction; P1, P2, P1- or P2-promoter of c-myc. (E, F)TAD, transactivation domain; DBD, DNA-binding domain; TRD, transrepression domain; EDA, essential domain for activation;...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "A High-Accurate Chinese-English NE Backward Translation System Combining Both Lexical Information and Web Statistics" pdf

... ,/log/1context possible of # while,1) ofContext ( Where NCTr and NCi denote the appearing times of the rth context CTr and the candidate Ci in the returned snippets respectively, and NPTi denotes ... recur-rences, and relative positions) are exploited to give these candidates a score. In the last step, the candidates with higher scores are sent to Google again. Recurrence information and relative ... the form of “Mr. and Mrs. Smith”, “Mr. And Mrs. Smith”, and so on. To deal with these aliasing forms, we transform all different forms into a standard form for the later ranking and identification....
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc

Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc

... ourunderstanding of the importance of different parts of the molecule and their flexibility in the process of amy-loid fibril formation often results more from a struc-tural analysis of the amyloid ... [120] and by heteronuclear NMR(human stefin A and chicken cystatin) [121,122]. The domain- swapped dimer of stefin A (Fig. 2A) is made of strand 1, the a-helix and strand 2 from one mono-mer, and ... templating and nucleation; (b)linear, colloid-like assembly of spherical oligomers; and (c) domain- swap-ping. In this review, we stress the role of domain- swapping and discuss therole of proline...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... Immunopre-cipitation assay (IP) of v-KIND from cerebellar lysates (input) by anti-MAP2 serum and normal mouse IgG as a positive and negative control,respectively. (C) Division of the middle CD2 region ... 32 residues of the mouse v-KIND KIND2 and 43 residues of the mouse MAP2 central domain. ThreeLeu residues at amino acid positions 461, 474 and 477 in the MAP2-bindingcore module of KIND2 contributed ... Flag-taggedv-KIND derivatives: v-KIND, full-lengthv-KIND; DKIND1, deletion of KIND1;DKIND2, deletion of KIND2; DKIND1 + 2,deletion of both KIND1 and KIND2; DRasN,deletion of RasN; DGEF, deletion of RasGEF;...
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