Tài liệu Báo cáo khoa học: "Detecting and Correcting Speech Repairs" ppt

... ours. A lot of speech repairs do not look ill-formed, such as " ;and a boxcar of- and a tanker of OJ", and " ;and bring - and then bring that orange juice," and are mainly signaled ... set. The speech repairs in the dialog corpus have been hand- annotated. There is typically a correspondence between the removed text and the resumed text, and following Bear, Dowding and Shriberg ... 24,000 words, 725 modification and abridged repairs, and 13 speakers; and for testing, 7 of the dialogs, consisting of 5800 words, 142 modification and abridged repairs, and seven speakers, none...

Tài liệu Báo cáo khoa học: "Detecting Semantic Equivalence and Information Disparity in Cross-lingual Documents" doc

... recognition where: i) T and H are in different languages, and ii) entail-ment relations between T and H have to bechecked in both directions. Using a combi-nation of lexical, syntactic, and semantic ... entailment-related prob-120lems. Given two pages (P1 and P2), these issuesinclude identifying, and properly managing:(1) Text portions in P1 and P2 that express the samemeaning (bi-directional ... wecombined the Europarl, News Commentary and “de-news”3parallel corpora. After tokenization, Giza++ and Moses were respectively used to align the cor-pora and extract a lexical phrase table (PT)....

Tài liệu Báo cáo khoa học: Applications and trends in systems biology in biochemistry docx

... Carbohydrate,glycolysisLactococcuslactisModeling Pi explicitly and regulationof pyruvate kinase (by Pi and FBP),PFK (by PEP) and GAPDH (byNADH) are critical to describeobservations (rapid increase in PEP,Pi and gradual decrease ... metaboliteconcentrations and metabolic ﬂuxes,both measured and nonmeasured. Ageneral parameter sensitivityanalysis is carried out to determine and characterize the parametershaving the most and least effectson ... lysineconcentration) were predicted and tested successfullyODE ss, sim,MCAMATLAB NG Time series of metabolitesmeasured by HPLC and enzyme assays; biomass and cell numbermeasured byspectrophotometryHua...

Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

... H4-K5, K8 and K12 acetylation [136–138]. In yeast, this group ismade up of NuA4 and Piccolo NuA4 which both uti-lize Esa1 as the HAT, and Esa1 was found to be essen-tial for H4-K5, K8 and K12 ... acetylation and deacetyla-tion, and transient recruitment of remodellers and transcription factors.A cycle of transcription commences with the recruit-ment of transcription factors and co-factors ... exist within CGislands which are characterized by their very high CGcontent and have an intrinsic resistance to DNA meth-ylation. CG-island promoters tend to be constitutively and ⁄ or ubiquitously...

Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx

... tumors and cell lines, miR-17-5p and miR-20a are induced in a manner that dependson cyclin D1 and repress the expression of cyclin D1.Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedbackloop and ... transcription factors E2F and Myc but,in turn, miR-17-92 downregulates the expression ofE2F and Myc [52]. In tumor progression, the tran-scription repressors ZEB1 and SIP1 and the miR-200family ... repressingthe indicated targets and presumably hundreds of other as yetunidentiﬁed targets. (B) miR-34a and the miR-34a-binding site inthe 3¢ UTR of genes shown in (A).miRNAs and cell signaling A. Ichimura...

Tài liệu Báo cáo khoa học: MicroRNAs and epigenetics doc

... cancer.DNMT 3A and 3BDNMTs 1, 3A, and 3B are key DNA methylationenzymes. Recent studies in human cells have demon-strated that PRC2 and DNMTs are physically and functionally linked [76], and that ... (Mathworks, Natick, MA,USA), we compared localization and strand directionbetween miRNAs and transcripts (Refseq genes and mRNAs). Intragenic and intergenic miRNAs were deﬁnedby whether the miRNAs ... the RISC complex, and degrades themby the SKI complex and XRN1 [21]. For partiallycomplementary targets, the RISC complex decaps and deadenylates target mRNAs via the DCP1-DCP2 and CAF1-CCR4-NOT...

Tài liệu Báo cáo khoa học: MicroRNAs and cardiovascular diseases ppt

... disease and that,when miR-1 is overexpressed in normal and infractedrat hearts, this results in a slowed conduction velocity,excessively prolonged repolarization and the inductionof PVCs and ... arrhythmias. On the other hand, blockingmiR-1 function with antisense oligoribonucleotides wasfound to normalize the expression of Cx43 and Kir2.1,prevent QRS and QT prolongation, and reducearrhythmias ... proliferationboth in vitro and in vivo.Another study demonstrated that the angiotensin IItype 1 receptor (AT1R) and miR-155 are coexpressedin endothelial cells and VSMCs, and that miR-155translationally...

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... binding and cleav-age by ribonuclease A and variants at Lys7, Arg10, and Lys66. Biochemistry 37, 12121–12132.31 Anderson DG, Hammes GG & Walz FG Jr (1968)Binding of phosphate ligands to ... where Ii(h) and I(h) are the ith and the meanmeasurements of the intensity of reﬂection h, respectively. Rcryst= Rh|Fo) Fc| ⁄ RhFo, where Fo and Fcare the observed and calculatedstructure ... useful for both studying and controlling the functionsof enzymes and other proteins. The most useful probes have high afﬁnityfor their target, along with small size and resistance to degradation....

Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc

... activation site (R144, N154, I152) and three in thesecond (F127, M436 and H428), and found that Ap4A and ADP interactwith the same site, but the sites for ATP and BPG remain uncertain. Thestructural ... cN-II, cN-III, cN-IA and cN-IB, and both cytosolic and mitochondrial 5¢(3¢)-deoxyribonu-cleotidases [5]. Even though all soluble 5 ¢-nucleotidasesshare the same reaction mechanism and possess con-served ... inosine and IMP remains unaltered, and the effect of theenzyme activators ATP and Mg2+is also unchanged(Table 1). Furthermore, by simultaneously measuringthe rate of nucleoside and phosphate...

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... HPRT and hypoxanthine. (C) PRTFDC1 and guanine. (D) HPRT and guanine.Table 2. Km and Vmaxvalues for Hx and G in the presence of 1 mM PRPP, determined using the DE-81 ﬁlter paper assay and ... domain is mainly builtup by residues from the C-terminus and consists of atwo-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig. 1A). Thetwo subunits ... (A) mono-mer and (B) tetramer generated using sym-metry-related molecules. Interactions withGMP (C). GMP, phosphate and calcium ionsare shown as sticks and spheres coloredpink and black, respectively.Studies...

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