... emerging targets for treatment of obesity and related metabolic diseasesTsuyoshi Kadomatsu, Mitsuhisa Tabata and Yuichi OikeDepartment of Molecular Genetics, Graduate School of Medical Sciences, ... normally, it is predicted that thesuppression of ANGPTL2 signaling has few sideeffects. Therefore, for these reasons, we consider thatthe suppression of ANGPTL2 signaling as a therapeu-tic strategy ... induces a state of ‘leptin resistance’in obese animals and humans resulting in development of hyperleptinemia. Similarly, hyperleptinemia is aconsequence of the development of insulin resistancein...