... for t-PA-induced intracranial bleeding in mousemodels of focal stroke [37]. In this model, co-treatmentwith the broad-spectrum MMP inhibitor GM6001effectively reduced intracranial bleeding. Morerecently, ... metalloproteinases, theirinhibitors, and laminin in stroke patients: in uence ofdifferent therapies. Stroke 34, 2165–2170.26 Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A,Smith JW, Liddington ... forangiogenesis and recovery? In this minireview, we sur-vey a few key events in the neurovascular unit, includ-ing blood–brain barrier (BBB) perturbations, matrixproteases, coupling between neurogenesis...