Tài liệu Báo cáo khoa học: "Exploiting Structure for Event D

Tài liệu Báo cáo khoa học: "Exploiting Structure for Event Discovery Using the MDI Algorithm" doc

... we investigate event discovery using a corpus of news articles relating to the recent Iraqi War where the tar- get event is the “Death” event type. Figure 1 shows a sample article depicting such events. The ... text, extract the relevant arguments of the event, and represent the extracted information into a structured form (Grishman, 1997). The types of events to ex...

Ngày tải lên : 20/02/2014, 12:20

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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx

... in 3.7% (v/v) formaldehyde in NaCl/P i for 5 min at room temperature. For experiments at 4 °C, the protocol was the same except that all incubations were performed at 4 °C until the end of the ®xation ... not alter the uptake of the Tat CPP. These biochemical evidences con®rmed a pathway for the e ntry of the Tat peptide unrelated to the HS proteoglycan receptors. Inte...

Ngày tải lên : 21/02/2014, 03:20

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Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt

... to another conformation to open the T2 channel (Fig. 3B). On the basis of protein structure libraries, the ‘open conformation’ would be the second most favoured conformation. On the other hand, ... are therefore EPR silent, although these coppers cause absorbance at 330 nm. The loops surrounding the T1 copper form the phenolic substrate-binding site of the enzyme, wherea...

Ngày tải lên : 14/02/2014, 18:20

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Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... were recalculated. The normalized B factors from apo importin-a were then subtracted from those in the importin-a:CLIC4 NLS structure, and the difference was again normalized using the equation above. The ﬁnal ... competes for the importin-a binding site, reducing binding afﬁnity for cargo proteins and help- ing to facilitate the release of the cargo within the nucleu...

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... groups: one with almost the same activity in the Mn- and Fe-forms, and the other exhib- iting low activity in the Fe-form and high activity in Mn-form. ApeSOD belongs to the latter group [16]. This ... perspective because the ter- tiary structure of ApeSOD has not been elucidated. In the present study, for the ﬁrst time, we describe the crystal structure of ApeSOD. In...

Ngày tải lên : 14/02/2014, 22:20

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Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

... wild-type and mutant structure are in the same range as the differences between the two molecules of the asymmetric unit of the wild-type structure. Neither the mutation nor the different crystallization ... protein. The atomic displacement factors of the PhyK structure are smaller for the a ⁄ b domain than for the a domain. This has also been observed for o...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

... important for the activity. Given the 3D structure of the HtA active site, and the interactions between side chains, we propose that D40, H42, R95 and F126 also form part of it. As in other ribotoxins, ... 0.98 A ˚ for all backbone atoms), and the glo- bal fold is similar to that reported for cytotoxins. However, differences can be found in the conformation of loops, the...

Ngày tải lên : 18/02/2014, 08:20

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Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx

... identical residues. The topological equivalence of the four TTSPs forms the basis for the sequence alignment shown in Fig. 3. The numbering in the alignment refers to the chymotrypsin numbering. Despite the high ... below). The southern boundary of the active site cleft of DESC1 is formed by the 145 autolysis loop. The backbone of this loop differs mark- edly from t...

Ngày tải lên : 19/02/2014, 00:20

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Tài liệu Báo cáo khoa học: Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus doc

... 1.0 A ˚ for the Ca atoms. Thus, the movement of the a2 helix accounts for 23% of the rmsd value (i.e. for approximately one quarter of the structural difference between the enzymes). These localized ... the quartenary structure of the BcZBP in solution is the hexamer found in the crystals and that this hexamer probably corresponds to the biologically active form...

Ngày tải lên : 19/02/2014, 00:20

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Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt

... important in the inhibitory mechanism, in addition to the primary structure of the peptide. To conﬁrm our hypothesis that the b-turn structures are important for the inhibitory activities of the peptides, ... better than cER. The cER peptide may potentially bind to the CD58 protein as indicated by the docking studies. The lowest energy docked structure was at the t...

Ngày tải lên : 19/02/2014, 13:20

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