... thatincludes a DNA-binding domain, a ligand-bindingdomain and a transactivation domain. The DNA-bind-ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... domain involved in protein–protein interactions. FYRC and FYRN domains are involved in heterodimerization between MLLN and MLLCterminal fragments. High-mobility group (HMG) domains areinvolved ... transformation.Thus, diverse DNA-binding domains, protein–proteininteraction modes and pre-existing chromatin modifica-tions may facilitate the binding of MLLs, depending onthe context and cell types, to...