... p38a, one of the four p38 iso-forms, is required for Bax activation and apoptosis.Because activation of p38 by UVB irradiation inhuman keratinocytes results in induction of a confor-mational ... phos-phorylation state of their proteins, thereby changingthe amount and localization of Bcl-2 family members.However, each type of cancer has its own way of disrupting the balance of the networks of signalingcascades ... might be a molecular target for the induction of apoptosis by TKIs.Inhibition of cell proliferationEGFR signaling activates a variety of pathways suchas those for cell survival, cell proliferation,...