... embryogenesis and adulthood, and functions by binding with two tyrosine kinase recep-tors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR ⁄ Flk-1),Fig. 1. The VEGF–VEGFR system and theinhibitors of various ... the Future’ of the Japan Society for thePromotion of Science, and the program ‘Promotion of Fundamental Research in Health Science’ of the Organi-zation for Pharmaceutical Safety and Research. ... here (Fig. 1), followed by discussion of two pathological conditions of angiogenesis in thebrain, stroke and brain tumors, along with possibletherapeutic strategies.VEGF and VEGFRsThe VEGF familyThe...