Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... mechanism of lactoperoxidase and
myeloperoxidase
A reflection on some controversial features
Elena Ghibaudi and Enzo Laurenti
Dipartimento di Chimica I.F.M., Universita
`
di Torino, Italy
Although ... formulated a hypo-
thesis that describes an integrated vision of the catalytic
mechanism of both enzymes. The main points are: (a) a
re-evaluation...
... ratios: at a 1 : 1 Fe
2+
⁄ protein ratio,
the resonances of Arg20, Asp22 and Asp23 disap-
peared, and the resonance of Leu21 shifted. At a 2 : 1
ratio, the resonances of residues 19 and 44 also ... spectrum of
CyaY, but the most striking consequence of the addi-
tion was the total disappearance of specific resonances
without the concomitant appearance of o...
... the
V20 5A mutant (B) and WT AtdA3 (C). Also
shown are the mononuclear iron (brown
sphere) and the catalytic facial triad of
H204, H209 and D356. (D,E) Molecular sur-
faces of the substrate channel ... deletion assay, the
atdA1 gene was amplified using the A1 _EcoRI_F and
A1 _SalI_R primers. The atdA2 gene was amplified using the
A2 _FseI_F and A2 _AvrII_R p...
... pair similarity computation since the other
parts of speech (adjectives and adverbs) do not have
a taxonomic representation structure. For example,
the jcn similarity measure (Jiang and Conrath, ... [SE07], and Semcor.
We tune the parameters in wmfvec and other base-
lines based on SE2, and then directly apply the tuned
models on other three data sets.
Data: The se...
... were
Table 3. Specificity of monoclonal anti-(human transcobalamin) sera and their effect on the functional properties of transcobalamin. nd, not
done.
mAb
Epitope
cluster
Precipitation of
Apo-TC ... the maximal
mAb ⁄ heparin effect on the functional activ-
ity of TC. Arrows show the hypothetical
movement of the domains after attachment
of Cbl, see the main text....
... domains, Movie, Job
and National Park, and had them manually anno-
tated. The annotation was given on both segmen-
tation of the queries and classification of the seg-
ments according to the label ... tagged
as Brand. In particular, Li et al. leveraged click-
through data and a database to automatically de-
rive training data for learning a CRF-based tagger.
Manshadi...
... polar-
ity. They assign any given word the label of its syn-
onyms or the opposite label of its antonyms if any of
them are known.
Kanayama and Nasukawa (2006) used syntactic
features and context ... construct a network
of words using gloss definitions, thesaurus and co-
occurrence statistics. They regard each word as an
electron. Each electron has a spin and each spi...
... GCCCCATGGCGGTGGATGGCATATGGGAGG
GGGTACCC
PrP105–231 GGAACAAGCCCAGCCATATGAAAACCAACC
TCAAGC
PrP113–231 CCAACCTCAAGCATATGGCAGGG
PrPD35–45 GGGTGGAACACCGGTGGCAACCGTTACCC
PrP112–119 CCTCAAGCATGTGGTAGTGGGGGGCC
PrPD112–136 CCAACCTCAAGCATGTGATGATCCATTTTGGC
PrPD135–150 ... 112–136
constitute part of the functional domain of the protein
provides a plausible explanation for the high evolutiona...
... 1 N , and then determines the mean and
standard deviation of the criterion function. Then,
a score is computed for each value of k by sub-
tracting the mean from the criterion function, and
dividing ... and
the 6 sense noun line. We also created 19 name
conflations where sets of 2, 3, 4, and 6 names of
persons, places, or organizations that are included
in the E...
... 2007; Kazama and Tori-
sawa, 2007).
As of today, only a partial comparative picture
is available regarding the actual utility and limi-
tations of available resources for lexical-semantic
inference. ... inference, are commonly utilized by ap-
plied inference systems (Giampiccolo et al., 2007)
and applications such as Information Retrieval and
Question Answering (Shah and Cro...