Tài liệu Báo cáo khoa học: Oxygen tension regulates the expression of a group of procollagen hydroxylases docx

... as the relative mRNA/b-actin mRNA ratio. The mRNA/b-actin mRNA ratio of the time standards (pools)cDNA was set to 1.0 (i.e. normoxia, 21% oxygen) . Dataare therefore expressed as relative values ... alpha ISense:5¢-CGGGATCCTCGGACACCCTGTAAATG-3¢Antisense:5¢-GGAATTCCAAGCAGTCCTCAGCTGT-3¢Mouse (gi:6754969) prolylhydroxylase alpha IISense:5¢-CGGGATCCTGCAGGCAGAATTCTTCA-3¢Antisense:5¢-GGAATTCCCAGTCTGTGTTCAACCG-3¢Rat ... and lysylhydroxylases mRNAs.Mouse (gi:836897) prolylhydroxylase alpha ISense:5¢-CGGGATCCTAGACCGGCTAACAAGTA-3¢Antisense:5¢-GGAATTCCAAGCAGTCCTCAGCTGT-3¢Rat (gi:474939) prolylhydroxylase alpha...

Tài liệu Báo cáo khoa học : Các phương thức thể hiện lời nói trên đài phát thanh docx

... kien nha bdo vdn phai phu Uiudc vao van ban. Didu dd cung cd ngbia la, gia noi rod vao vj tri giao nhau giua dpe va noi song vdn dya chu yeu vao cdc tieu chuan eua dgc. O dja hat ngdn ... nhanh nhat, cudng do manh nhat: Va biy gid, cic ban co biet vi khich mdi tiip theo cua chung ta la ai khdng a? Laaia? Vang, hiy cung hudng lin sin khiu va ndng nhiit chio don: ca ... didu nay, ngugc lai, da anh hudng tryc tiep tdd tam ly, ngdn ngu cua hg. Ngudi ndi khdng the yen tam dya hoan toan vao cdc van ban viet sdn, ma da ed phuang thdc "kbdu ngu boa",...

Tài liệu Báo cáo khoa học: Inorganic phosphate regulates the binding of coﬁlin to actin ﬁlaments pdf

... in the medium, there is alwaysATP or ADP–Pi in the cleft of actin protomers locatedin the vicinity of the barbed end of the filament, pro-ducing an ATP or ADP–Pi cap at this end. Because of the ... presence of this cap at the barbed end the criticalconcentration for polymerization of F-actin is low.F-ADP-actin can also be polymerized from ADP–G-actin in the absence of ATP. In this case all the ... of actin filaments and accelerate their treadmilling [2].AC proteins accelerate the turnover of actin filamentsby severing them [3–6], thereby increasing the number of the free pointed and barbed...

Tài liệu Báo cáo khoa học: "Learning to Compose Effective Strategies from a Library of Dialogue Components" doc

... the total reward expected be-tween taking that action and the end of the dialogue.For each state-action pair (s, a) , we calculated thisexpected cumulative reward Q(s, a) of taking action a from ... Dialogue state/action management The dialogue state is unique at every stage of the conversation and is represented as a vector of feature-values. We use only a limited set of fea-tures because, ... (sum) of the rewards for all evalu-ation measures. We found that the learned policybased on the combination of all measures, and the policy based on measure M1 alone (Overall, thisconversation...

Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx

... Subbuswamy K. Prabu1,*, Cynthia M. Otto2and Narayan G. Avadhani11Department of Animal Biology and2Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania,Philadelphia, ... shown in Table 2, there was a markeddifference in the total cell ATP synthesis as well asmitochondrial respiration-coupled ATP synthesis inmacrophages and PC12 cells. The rate of ATP synthesisin ... in yeast have demonstrated that oxygen acts as a molecular switch and alters the expression of the twonuclear genome coded isoforms of CytOX V [10,32]. The regulation of genes CytOX 5a and CytOX5b,...

Tài liệu Báo cáo khoa học: Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation pdf

... for asparaginein the CAD of HIF- 1a [95]. If the asparagine in the CADwassubstitutedwithanasparticacidresidue,FIH-1hydroxylase activity for the aspartic acid residue was only7% of that obtained ... revealed that HIF- 1a contained two transactivation regions, termed the amino-terminal transactivation domain (NAD) and the carboxy-terminal transactivation domain (CAD) [74,75]. Functionalanalysis ... revealed that the activity of both the NAD andCAD were enhanced by hypoxia treatment. Since the NADoverlaps with the ODD its increase in transcriptionalactivity at hypoxia was largely attributed...

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... or SYK themselves, is capable of transforming NIH-3T3 cells [70]. In addition, weand others have demonstrated that the activation andplasma membrane localization of the fusion constructare dependent ... F, Cazzola G, Consolini R, De Mattia D,Dell’Erba G et al. (2002) Clinical, immunological, andmolecular analysis in a large cohort of patients withX-linked agammaglobulinemia: an Italian multicenterstudy. ... Hussain1,2,*, Liang Yu1,3,*, Rani Faryal1,2, Dara K. Mohammad1, Abdalla J. Mohamed1,4and C. I. Edvard Smith11 Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet,...

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

... 173,2083–2090.12 Otake H, Masuyama H, Mashima Y, Shinomiya A, Myosho T, Nagahama Y, Matsuda M, Hamaguchi S &Sakaizumi M (2009) Heritable artiﬁcial sex chromo-somes in the medaka, Oryzias latipes. ... copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes. Proc Natl Acad Sci USA 99,11778–11783.9 Matsuda M, Nagahama Y, Shinomiya A, Sato T,Matsuda C, ... Suzuki A, Kobayashi T, Paul-Prasanth B, Lau EL, HamaguchiS, Sakaizumi M & Nagahama Y (2007) DMY geneinduces male development in genetically female (XX)medaka ﬁsh. Proc Natl Acad Sci USA 104,...

Tài liệu Báo cáo khoa học: Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy pdf

... evidence of an  100 kDa C-terminal frag-ment in the normal control and DRPLA human brains[15]. Caspase cleavage of ATN1 at Asp109 generates a large C-terminal fragment [19–21], although whether the ... processing regulates pathologicalaccumulation in dentatorubral-pallidoluysian atrophyYasuyo Suzuki1, Kimiko Nakayama1, Naohiro Hashimoto2and Ikuru Yazawa11 Laboratory of Research Resources, ... data indicate that the amount of the full-length ATN1 and fragments increased in the COS-7 cells as the size of the polyQ was increased.Next, we assessed whether the quantitative increaseof...

Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx

... Uni-versity, and were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. All efforts were made to minimize the number of animals used and their ... in the nucleolus, nucleus and cytoplasm of the cell, aswell as at the cell surface [10]. Nucleolin ⁄ C23 regulates many aspects of DNA and RNA metabolism, such asRNA polymerase I-mediated transcription, ... in cardiomyocytes willprovide a molecular basis for new therapeutic strate-gies targeting speciﬁc pathways to treat human heartdisease.Materials and methodsAnimalsNeonatal Wistar rats (1-3...

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