Tài liệu Báo cáo khoa học: Mapping the functional domains of human transcobalamin using monoclonal antibodies pptx

... 656–677. Mapping of transcobalamin using antibodies S. N. Fedosov et al.3898 FEBS Journal 272 (2005) 3887–3898 ª 2005 FEBS Mapping the functional domains of human transcobalamin using monoclonal antibodies Sergey ... on the functional activ-ity of TC. Arrows show the hypotheticalmovement of the domains after attachment of Cbl, see the main text. Mapping of transcobalamin using antibodies S. N. Fedosov et ... described a number of TC monoclonal antibodies (mAbs) that interfere with the physiologicalfunctions of human TC, i.e. the Cbl and receptor bind-ing [16]. Therefore, a map of the corresponding...

Tài liệu Báo cáo khoa học: Mapping the functional domain of the prion protein docx

... certain domains of the protein decrease the SOD-like activity of the protein. The domains deleted were based on the epitopes of the antibodies that had a clear effect on SOD-like activity of PrP. The mutants ... on the SOD-like activity of PrP.Production of deletion mutants of PrPOn the basis of the results with antibodies, a series of PrPmutants were made to assess whether deletions of certain domains ... Several of the antibodies and antisera caused a concentration-dependent inhibition of the SOD-like activity of PrP. The ability of the antibodies and antiserum to inhibit the SOD-like activity of...

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... andregulators of other enzymes in the human nucleotidemetabolism (Table S1). The library can then be seen toconstitute the speciﬁc metabolome of the nucleotidemetabolism, which would be the most ... respectively, of that of HPRT. This low activitycould be explained by the fact that PRTFDC1 has a Gly in the position of the proposed catalytic Asp of HPRT. In PRTFDC1, a water molecule at the position of ... (Grenoble,France) using a wavelength of 1.04 A˚. The data were inte-grated using mosflm [29] and scaled using scala from the ccp4 software suit [30]. The structure was solved with the molecular...

Tài liệu Báo cáo khoa học: Understanding the binding properties of an unusual metal-binding protein ) a study of bacterial frataxin pdf

... resonanceswithout the concomitant appearance of other signalsin other parts of the spectrum. This result could be aconsequence of the paramagnetic properties of Fe(II),or it might arise from the presence of ... Fe3+Addition of Fe2+induced the displacement of severalresonances in the [1H,15N]-HSQC NMR spectrum of CyaY, but the most striking consequence of the addi-tion was the total disappearance of speciﬁc ... in the reﬁnement. The correctness of the modelwas checked using the procheck [43] and whatcheck [44]programs. The coordinates of the higher-resolution complexmodels have been deposited in the...

Tài liệu Báo cáo khoa học: Probing the molecular determinants of aniline dioxygenase substrate speciﬁcity by saturation mutagenesis docx

... [14]. The lack of characterization of the structural determinant of the substrate specificity of the AtdA enzyme has thus limited its development as abiocatalyst for the bioremediation of a wide ... reported which of the five genes control the substrate specificity of the AtdA enzyme. The objective of this study was to identify and probe the residues determining the activity as well as the sub-strate ... may indicate that the steric limitation of the enzyme’s binding pocket takes place in the areabetween the ortho and para positions of the aromaticsubstrate.On the basis of these results, aniline...

Tài liệu Báo cáo khoa học: "Learning the Latent Semantics of a Concept from its Deﬁnition" pptx

... words. Therefore,missing words can be used to prune the hypothesesthat are also highly related to the missing words.Consider the hypotheses of latent vectors in ta-ble 1 for bank#n#1. Assume there ... WMF on the deﬁnitions corpus, the similarity of two senses sjand skcan be computedby the inner product of Q·,jand Q·,k.2.3 A Nuanced Sense Similarity: wmfvecWe can further use the features ... vectors. Let N(j) be the set of neigh-bor senses of sense j. then new latent vector is:Qnew·,j= Q·,j+k∈N (j)kQ·,k(2) Inner product (in-stead of cosine similarity) of the two resulting...

Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reﬂection on some controversial features Elena Ghibaudi and Enzo Laurenti docx

... of these questions, we will proposea new hypothesis that describes an integrated vision of the catalytic mechanism of MPO and LPO.A brief survey of the absorption features of MPO, LPO and their ... oxidize them [19]. On the other hand, this factdoes not represent proof of the presence of one or twooxidizing equivalents on the decay product of Cpd I. The EPR spectrum of a spin-trapped radical ... pres-ence of H2O2alone, a non-physiological condition. Webelieve that the absence of direct evidence of the radical in the presence of cosubstrates limits the validity of extrapo-lating the model...

Tài liệu Báo cáo khoa học: "Understanding the Semantic Structure of Noun Phrase Queries" pptx

... bestIM:Type full timeIM:Title the godfatherOther the, in, that Other the, in, that Other the, in, thatTable 3: Label sets and their respective query segment examples for the intent class Movie, Job ... goal of this work is to identify the semantic labels of IMs,i.e., the attribute names they implicitly refer to. Weuse Acto denote the set of IM semantic labels for the intent class c.OtherAdditionally, ... wonderland 2010 cast”: (1) the Title of the movie is “alice in wonderland”; and(2) the Year of the movie is “2010”. Interestingly, the user does not explicitly specify the attributenames, i.e.,...

Tài liệu Báo cáo khoa học: "Identifying the Semantic Orientation of Foreign Words" pdf

... al.,2010), where the attitude of participants in a discus-sion is inferred using the text they exchange.Due to its importance, several researchers haveaddressed the problem of identifying the semanticorientation ... engine. The number of hits for positive seeds, negative seeds,positives seeds near the given word, and negativeseeds near the given word are used to estimate the association of the given word to the ... polarity,hitsw,posis the number of hits returned by a com-mercial search engine when the search query is the given word and the disjunction of all positive seedwords. hitsposis the number of hits when...

Tài liệu Báo cáo khoa học: "ON THE AUTOMATIC TRANSFORMATION OF CLASS MEMBERSHIP CRITERIA" docx

... checks whether required components of the definition of the class are also present in the description of the instance. This also permits easy representation of modifications to the definition, ... irrelevant to the matching process. The transformation is performed by means of a process of ~ inmtRntlat~nn OF the deflnition the translation of the de/initlon f~'om a set of criteria ... characterization is being sought, or the modification of the criteria by means of which a characterization is found. The choice between these two responses (or of the way in which they are combined) appears...

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