Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx

... hp2bs CCCCTGATGGGGGCGTATTTCCACCATGAATCACTCCCChp2b hp2br GTGATTCATGGTGGAAATACGCCCCCATCAGGGGGCTGG(–)IRES LDH2s TTTTGCGGCCGCGCCAGCCCCCTGATGGGGGCGCAGCCTCCAGGALDH2 CCCCCCCTCCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTTTTLDH2r ... 5’341T7TAATACGACTCACTATAGGGTGCACGGTCTACGAGACCT(–)IRES DSLA1 GCCAGACACTCCACCATGAATCACTCCCCTGTGAGGAACTACTGTCTTCACGDSLA1 5’341T7TAATACGACTCACTATAGGGTGCACGGTCTACGAGACCT(–)IRES DHp2s TTTGCGGCCGCGCCAGCCCCCTGATGGGGGCGACACTCCACCATGAATTCTDhp2 ... CCCCCCCTCCCGGGAGAGCCATAGTGGTCTGCGGAACCGGTTTTLDH2r AAAAACCGGTTCCGCAGACCACTATGGCTCTCCCGGGAGGGGGGGTCCTGGAGGCTGCGCCCCCATCAGGGGGCTGGCGCGGCCGCAAAA(–)IRES 239rTAATACGACTCACTATAGGGGCACGCCCAAATCTC239 5’S2 GCCAGCCCCCTGATGGGGGCGA(–)IRES...

Tài liệu Báo cáo khoa học: Afﬁnity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

... [125I]TC-PCSK9 binding increased as cell surface LDLR densityincreased. Unlabeled wild-type and two gain -of- function mutants of PCSK9 reduced binding of [125I]TC-PCSK9. The Scatchard plot of the binding- inhibition ... HepG2cells increased following growth in the absence of lipo-proteins, and there was a corresponding increase in the binding of [125I]TC-PCSK9 and [125I]TC-PCSK9-D374Y. Second, the extent of ... whether the kinetics of binding of PCSK9 to HepG2 cells can be described as a simplebimolecular reaction, the kinetics of [125I]TC-PCSK9 and [125I]TC-PCSK9-D374Y dissociation from and association...

Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

... other bacteria. Itsinteraction with macrophages induces a decrease in the production of the pro -in ammatory cytokines tumournecrosis factor-a and interferon (IFN) -c and an over-production of ... tobe the only one that is common to all bacteria. In Yer-sinia, the increased synthesis of LcrV triggered by the activation of the system leads to the titration of LcrG,which binds LcrV in a ... for the injection of type III effectorsinto the target cytoplasm and therefore are consideredto be the ﬁrst substrates secreted by the T3SS needleupon cell contact. In the absence of external...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebraﬁsh, Danio rerio docx

... GTCCAGAATATTCAGCCTTTCACC 3¢-RACEZftbet-F1 CTCCCTCAAACAAACCAGAGTC Initial PCRZftbet-R1 CACTGGATGAGACAGGAAGTT Initial PCRZf3¢tbet-F1 CTTCTCCAGGACAGTCCAAAGAGTC 3¢-RACEZf3¢tbet-F2 CTGGATTGAAGCGCCCTCGGTTAATC ... ATGCTCATCAGTAGATTCTGCTCAC Real-time PCRZFil10-F ACGCTTCTTCTTTGCGACTG Real-time PCRZFil10-R CACCATATCCCGCTTGAGTT Real-time PCRZfgata3-F GCTTCTTCCTCCTCGCTGTC Real-time PCRZfgata3-R TGCACTCTTTGTCTTCCTGTCG ... CTGGATTGAAGCGCCCTCGGTTAATC 3¢-RACEZf5¢tbet-R1 GCTGCCTTTGTTATTTGTAAGCTTCAG 5¢-RACEZf5¢tbet-R2 GGAAACTTCCTGTCTCATCCAGTG 5¢-RACEZffoxp3-F1 GGAACACACAGAGGGGATGATA Initial PCRZffoxp3-R1 CTTCAACACGCACAAAGCAC...

Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

... (Roche Diagnostics) and the following PCR primer sets: 5¢-GGAGATCTCCAGTGATATCGACCA-3¢ and 5¢-ACGGCTTCTACGGATCGAAACT-3¢ for PPARc ,5¢-AAGACAGCTCCTCCTCGAAGGTT-3¢ and 5¢-TGACCAAATCCCCATTTACGC-3¢ ... aP2,5¢-ATCCATGGATGGACGGTAACG-3¢ and 5¢-CTGGATCCCAATACTTCGACCA-3¢ for LPL, 5¢-TGGGTTGGCTGCTTGTG-3¢ and 5¢-GCGTGGGCAGGATGAAG-3¢for SCD, 5¢-GATGTGGAACCCATAACTGGATTCAC-3¢ and 5¢-GGTCCCAGTCTCATTTAGCCACAGTA-3¢ ... 5¢-GGTCCCAGTCTCATTTAGCCACAGTA-3¢ forCD36, 5¢-GCGTCGGGTAGATCCAGTT-3¢ and 5¢-CTCAGTGGGGCTTAGCTCTG-3¢ for ACC, and 5¢-AACACCCCAGCCATGTACGTAG-3¢ and 5¢-TGTCAAAGAAAGGGTGTAAAACGC-3¢ for b-actin. Expression levels of the target...

Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

... most convincingevidence supporting this hypothesis was the rescue of the bone mass phenotype of the ob ⁄ ob mice byintracerebroventricular (ICV) infusion of leptin in the hypothalamic region, clearly ... demonstrating that the inhibitory action of leptin on bone formation is medi-ated by a central circuit [25]. Further supporting the importance of leptin in the control of bone formation,mice lacking ... Referencesob ⁄ ob Leptin Increased TBVDecreased CBVIncreased in trabecular boneIncreased Increased NPY levels 25,46db ⁄ db Leptin receptor Increased TBV Increased Normal ND 25Y2) ⁄ )Y2 Increased...

Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through speciﬁc protein interactions in the methionine synthase–methionine synthase reductase complex docx

... cob(II)alamin. Reduction of the Co centrepromotes the dissociation of the lower dimethylbenz-imidazole base of the cofactor. Consistent with this, the crystal structure of the cobalamin -binding domainHomocysteineMethionineCoMethylcob(III)alaminCob(I)alaminPrimaryturnovercycleHCH3H4folateAdoHycCob(I)alaminCob(II)alaminH4folateCoNADPHAdoMete–FADFMNNADPHNADP+e–ReactivationCoFig. ... turnover, the homocysteine -binding domain (dot-ted barrel) and the CH3-H4-folate binding- domain (black barrel) form discrete complexes with the cobalamin -binding domain (dark grey circle).hMS ... MSRresults in a quenching of the intrinsic flavin fluores-cence, suggesting that the flavin chromophore isshielded from the solvent in the protein–protein com-plex [19]. From the fluorescence titration...

Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulﬁde isomerase family proteins with nonclassic active center motifs pdf

... levels of both b-conglycinin and glycinin,as pro-b-conglycinin and proglycinin are transient pro-tein forms that are present in the ER prior to process-ing in the protein storage vacuoles. The synthesis ... third amino acids in classic redox-active CGHC motifs with methionine or isoleucine and asparagine in GmPDIL-3a and GmPDIL-3b maybe the cause of the lack of such enzymatic activities.Alternatively, ... thisis the ﬁrst report to conﬁrm expression of such pro-teins in the ER of plants. A CXXS motif and aCXXC motif in the N-terminal and C- terminal thi-oredoxin domains and the surrounding sequences...

Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt

... bySREBP- 1c in the liver inhibits processes regulatinginsulin signaling, such as glycogen synthesis, and con-tributes to the physiological switching from glycogen synthesis to fatty acid synthesis during ... hepatosteatosis and pancreatic b-cell dysfunction [25,26].Insulin resistance in liver and impairedinsulin secretion in b-cellsMolecular dissection of the underlying mechanisms of lipotoxicity due to cellular ... isproduced from glycolysis of glucose, and passed into the tricarboxylic acid cycle orused for fatty acid synthesis or cholesterol synthesis. SREBP-2 regulates cholesterolsynthetic genes in a...

Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins pptx

... employed these toxins(mainly OA) to examine cell–matrix interactions and cell–cell contacts, either directly by controlling struc-tural adhesion proteins, or indirectly by affecting pro-teins involved ... activity. Among the structures implicated in cell–cell interactions, tight junctions are specializedcontact sites between the cell membranes of adjacentcells in which the intercellular space ... protein phosphatases are involved is immense,including regulation of glycogen metabolism and coor-dination of the cell cycle and gene expression. The crit-ical importance of phosphatases in cell...

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