Tài liệu Báo cáo khoa học: Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis docx
Tài liệu Báo cáo khoa học: Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis docx
... Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis Jodie L. Guy, Richard M. Jackson, ... CL1 by 20.7 A˚ in tACE and iscoordinated by residues in subdomain I), it may beimportant for stabilizing complex formation for those residues in subdomain II involved directly in substratebinding ... The zinc protease domain is divided into two sub-domains, which are defined by the movement of thesubdomains relative to each other upon inhibitor bind-ing. Subdomain I (N-terminal) contains...
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Tài liệu Báo cáo khoa học: Identification of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein ppt
... the guanidini-um group of the Arg in the RGG domain in theC-terminal of EWS.Results and DiscussionSeveral DNA-binding proteins that bind to G-quadru-plex DNA have been investigated in vitro ... the RGG domain of nucleolin,a DNA-binding protein contributing to the transcrip-tion of ribosomal RNA, bind to the G-quadruplexforming ribosomal DNA [26]. Moreover, nucleolinbinds to the ... affinity of EWS and RBD toHtelo.Fig. S4. In vitro arginine methylation of RGG3 by PRMT3.Fig. S5. Identification of significant residues at RGG3for rHtelo binding ability.Fig. S6. Ability of RGG3...
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Tài liệu Báo cáo khoa học: Identification of two late acyltransferase genes responsible for lipid A biosynthesis in Moraxella catarrhalis doc
... two mutants in bacterial clearance might reflectdifferences in the integrity of their outer membrane,binding activity and sensitivity of the murine comple-ment-mediated killing. In conclusion, ... After 24 h of incubation, theresulting Zeorcolonies were selected for PCR identification using primers b1X and b1B, and the inactivated lpxXmutant was verified by sequencing.Cloning of lpxL and ... (1.9 lg of protein concentration) were resolved by 15% SDS ⁄ PAGE and visualized by silver staining [49].Structural analysis of lipid AThe LOS from 30–35 g of wet cells of each strain wasprepared...
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Tài liệu Báo cáo khoa học: Identification of differentially expressed genes of the Pacific oyster Crassostrea gigas exposed to prolonged thermal stress docx
... Raychaudhuri S, Sinha M, Mukhopadhyay D & Bhat-tacharyya NP (2007) HYPK, a Huntingtin interactingprotein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2Acells ... number of genes encoding structural components of the cytoskeleton and proteins involved in contractilefunctions (including actin, tubulin myosin and profilin)were differentially expressed in C. ... chapero-nin-containing TCP1 (subunit 7, isoform b) presentedthe same expression pattern in response to heat stress in our study. This complex, involved in folding actin,tubulin and cyclin E, among...
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Tài liệu Báo cáo khoa học: Identification of a novel matrix protein contained in a protein aggregate associated with collagen in fish otoliths pdf
... differentdomains of the protein, to determine the calcium-binding domain of the protein. (A) Schematic drawing of the recombinant proteins. SixGST-fused recombinant proteins containing the three distinctivedomains ... Pi, and specificbinding of the antibody was detected by incubating thesections in a solution of 10 mm diaminobenzidine in 10 mm NaCl ⁄ Pi.H. Tohse et al. A novel protein in the otolith matrix ... structures in the otolith matrix. Overall, OMM-64, by forming a calcium-binding aggregate that binds to otolin-1 and formingmatrix protein architectures, may be involved in the control of crystalmorphology...
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Tài liệu Báo cáo khoa học: Identification of b-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay docx
... out by heterologous expression in yeast.Results and DiscussionP450 genes induced by elicitors in the cell culture of G. maxAccumulation isoflavones phytoalexin glyceollins, in the seedling infected ... understanding of the biosynthesis of triterpenesaponins is required, including the enzymes catalyzingthe sequence of reactions and the genes encoding theseenzymes.The biosynthesis of triterpene ... include a number of active constituents of medicinal plants, as exemplified by glycyrrhizin in Glycyrrhiza glabra, ginsenosides in Panax ginseng, sai-kosaponins in Bupleurum falcatum, etc. [1]. Extensivepharmacological...
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Tài liệu Báo cáo khoa học: Identification of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent doc
... in the absence of the STAT2 DNAbinding domain as revealed by real-time PCRTo more quantitatively examine the expression of IFN-regulated genes in the absence of the STAT2 DNAbinding domain, ... DNA binding, and compared the cDNAs of IFN-treated cells over-expressing intact STAT2 to those of IFN-treated cells overexpressingmutated STAT2 lacking the DNA binding domain. The IFN-inducibleexpression ... Thus,IFN-inducible expression of these genes is impaired in the absence of the STAT2 DNA binding domain, sug-gesting that their IFN-inducible transcription requiresISGF3-independent STAT2-containing...
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Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc
... FEBSAnalysis of serine proteinases secreted by various cell linesTrypsin-type serine proteinases present in the condi-tioned media of the nine cell lines were analyzed by gelatin zymography ... 2006 FEBS 627 Identification of membrane-bound serine proteinasematriptase as processing enzyme of insulin-like growthfactor binding protein-related protein-1(IGFBP-rP1/angiomodulin/mac25)Sanjida ... follows: aprotinin, leu-peptin, pepstatin A, AEBSF and proteinase inhibitor mixturethat contains AEBSF, aprotinin, bestatin, E-64, leupeptinand pepstatin A from Wako Pure Chemical Industries(Osaka,...
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Tài liệu Báo cáo khoa học: Identification of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae docx
... 4.9aThis strain was grown in media lacking leucine. The other strainswere grown in media containing leucine.Fig. 5. Complementation of pos5 cell. Indi-cated pos5 and WT cells carrying each geneon ... biosynthesis(nicotinic acid mononucleotide, nicotinic acid adeninedinucleotide, nicotinic acid and quinolinic acid) did notinhibit Yef1p (Table 2). HgCl2inhibited enzyme activity(Table 2), thereby indicating ... min at 30 °C in an initial reaction mixture (1.0 mL),and specific activity was expressed in UÆmg)1protein. Vmaxwas determined using 1.0 U Yef1p or Utr1p, being defined by an assay of NAD kinase...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
... thequantitation of microgram quantities of protein utilizing theprinciple of protein-dye binding. Anal. Biochem. 72, 248–254.20. Laemmli, U.K. (1970) Cleavage of structural proteins during theassembly of ... in the amino acid sequence, increasing the number of basic residues of lysine, arginine and histidine, could occur.However it seemed probable that the eEF1A isoformscould act as a controlling event ... protein belonging to the GTP-binding elongation factor family, which promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis and the capture of deacylated...
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