... integrin-dependentcell volume sensing and signaling integrates into theoverall context of insulin signaling. Similarly, sensingof glutamine-induced hepatocyte swelling by integrinsfeeds into ... swelling [12–14].Integrin-inhibitory peptides exhibiting an arginine-gly-cine-aspartic acid (RGD) motif abolish hypoosmoticosmosignaling towards Src-type kinases, mitogen-acti-vated protein kinases ... swelling[13], indicating that inhibition of osmosensing at theintegrin level uncouples hepatocyte swelling fromosmosignaling and its functional consequences.Like hypoosmotic hepatocyte swelling...