... (DAPK-1) is aCa2+⁄ calmodulin-regulated serine ⁄ threonine kinasecomposed of multiple functional domains, including akinase domain, a calmodulin-binding domain, eightankyrin repeats, two P-loop ... ⁄ ERK signaling pathway [3]. Moreover, agermline mutation in the death domain of DAPK-1has been found to reduce intrinsic oligomerization of the death domain, disrupt the binding of ERK, andthus ... from the DAPK-1 locus (named s-DAPK-1). This encodes a 295 amino acidpolypeptide encompassing part of the ankyrin-repeat domain, the P-loopmotifs, part of the cytoskeletal binding domain of DAPK-1,...