Tài liệu Báo cáo khoa học: Binding of ligands originates small perturbations on the microscopic thermodynamic properties of a multicentre redox protein pptx
... FEBS
Binding of ligands originates small perturbations on the
microscopic thermodynamic properties of a multicentre
redox protein
Carlos A. Salgueiro
1,2
, Leonor Morgado
1,2
, Bruno Fonseca
1,2
, ... with data
for the isolated cytochrome shows that binding of ligands causes only small
changes in the reduction potentials of the haems and their...
... translation. Half of the translations are
correct translations (A and B), while a third are
partially correct translation (P). Notice that it is a
common practice to translate only the surname ...
outside of translations. In Figure 1, the translation
艾美獎 (ai mei jiang) are labeled as B I I, while all
other Chinese characters are labeled as O. An
additional tag of E...
... knowledge, the consequence is that a
large quantity of analyzed language data can be found
on the Web. In many cases, the data is richly annotated
and exists for many languages for which there would
otherwise ... limited annotated data. The resource,
the Online Database of INterlinear text (ODIN), makes
this data available and provides additional annotation
and structure, ma...
... sheep and
goats.
The main characteristic of the disease is the accumu-
lation of an abnormal prion protein (PrP
Sc
), thought
to be the only infectious agent associated with prion
neurodegeneration ... molecular masses
are the di- and mono-glycosylated isoforms and the
band with the lowest molecular mass is nonglyco-
sylated PrP
C
. Quantification of the three protein...
... MT1-MMP
activation of MMP-2, can also take part in the second
autoactivation step and function as an activator by
promoting conversion of the 64 kDa intermediate to
the fully active 62 kDa form. ... Further, autoactivation of
the active 62 kDa form to a C-terminally truncated
45 kDa form was also inhibited by TIMP-1.
Investigation of mechanisms that may explain
the increas...
... fungi and archaea). We compare 2,5-diamino-6-
ribitylamino-4(3H)-pyrimidinone 5¢-phosphate synthases from the yeast
Candida glabrata, the archaeaon Methanocaldococcus jannaschii and the
eubacterium ... riboflavin biosynthetic pathway in plants is similar
to that of eubacteria, rather than that in fungi and
archaea. In view of the close similarity between puta-
tive plant deaminases...
... obtain cDNAs encoding M25L–elafin and M63L–trap-
pin. For this purpose, forward primers 5¢-CGACTCGA
GAAAAGAGCGCAAGAGCCAGTCAA-3¢ and 5¢-CGAC
TCGAGAAAAGAGCTGTCACGGGAGTTCCT-3¢ were
used for amplification ... Pr3 was assessed by
adding a constant concentration of enzyme to increas-
ing concentrations of elastin, stirring for 10 min,
centrifugating the suspensions and measuring the
concent...
... concentrations of CCK-8, CCK-8-NS and eugenin. Con-
tractions were measured on a Maclab data recorder (Maclab, Castle
Hill, New South Wales, Australia) and expressed as a percentage
of the maximal ... separation. MS and MS ⁄ MS data on
the components of all HPLC fractions indicate the
presence of a variety of lipid, sugar and phosphate
Fig. 1. The young of Macrop...
... focus on the transcriptional unit coding
for the class A transcript, and refer to it and its regula-
tory regions as the Abd-B domain. The expression pat-
tern of Abd-B is regulated by a set of large ... abdominal segments A6 and A7 .
Although the iab-5 cis-regulatory region is
also in an active conformation in A6 , only
iab-6 is presumed to contact the Abd-B
promoter...
... proceeds with
similar activity at both individual sites; cleavage rates
are virtually identical, ligation rate constants vary by a
factor of only about 2.5.
Alteration of RNA sequence by the twin ribozyme
HP–TWRJ
The ... from ligation
of the 15-mer produced by cleavage in the first step of
the reaction to the added 20-mer fragment S20 cp.
This illustrates that ligation at...