... symptoms and pain. They become increasingly prevalent and obvious overthe course of the illness and are a major determinant of quality of life, progression of overall disability and of nursing-home ... meta-analysis of 17 randomised trials involving 3525 patients. BMJ, 329, 593.Jankovic, J., Schwartz, K. and Vander Linden, C. (1989) Compari-son of Sinemet CR4 and standard Sinemet: double blind and long-term ... 886.Alexander, G.M., Schwartzman, R.J., Grothusen, J.R. and Gordon,S.W. (1994) Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood-to-brain transport of levodopa...