... signaling through the low-density lipopro-tein receptor-related protein [31]. In vivo, t-PA wasshown to also directly open the BBB in models offocal ischemia with complex signaling actions involvingthe ... asecondary elevation in MMP-9 in endothelial and glialcells within networks of regrowing microvessels [60];and inhibition of MMPs during this delayed phaseactually made outcomes worse with the developmentof ... metalloproteinases, theirinhibitors, and laminin in stroke patients: in uence ofdifferent therapies. Stroke 34, 2165–2170.26 Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A,Smith JW, Liddington...