Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc

... Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats Rivelilson M. Freitas, Silvaˆnia M. M. Vasconcelos, ... nitrite content wereincreased after SE. Lipid peroxidation in the brain canFig. 1. Biochemical alterations in the hippocampus of adult rats after pilocarpine-induced SE. Male rats (250–280 g, 2 ... Interstrain differences in cognitive functions in rats in relation to status epilepticus. Behav Brain Res112, 77–83.3 Treiman DM (1955) Electroclinical features of status epilepticus. J Clin...

Tài liệu Báo cáo khoa học: Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus doc

... residue in the zinc-bound MshB structure (PDB code 1Q74) adopts a sim-ilar strained conformation. On the other hand, in the absence of a zinc ion in the active site, such as in the structures of the ... loop in the active site (e.g. in substraterecognition). The a2 helices in the BcZBP and TT1542 structuresare rotated relative to each other around theirC-termini; in BcZBP the N-terminus of the ... and the acetate, and suggests a possible role in the enzymaticreaction which will be discussed later. The structure of the active site, the type of proteinligands, the zinc-binding motif, the...

Tài liệu Báo cáo khoa học: Physiological relevance of the endogenous mono(ADP-ribosyl)ation of cellular proteins doc

... near the N-terminal portion of the protein and is characterizedeither by a conserved histidine (as in diphtheria toxin,ART3 and the PARPs) or by a conserved arginine(as in pertussis toxin, ... which include the purinergic receptor P2X7, the defensins and the integrins. Intracellularmono(ADP-ribosyl)ation modiﬁes proteins that have roles in cell signallingand metabolism, such as the ... amino acid of the acceptorprotein, with the creation of an N- or S-glycosidic link-age and the release of nicotinamide. The free amino acidarginine (the most frequently modiﬁed residue of the protein...

Tài liệu Báo cáo khoa học: Dimer asymmetry and the catalytic cycle of alkaline phosphatase from Escherichia coli doc

... cooperative inter-actions have been detected during metal-ion binding,positive for the binding of Zn2+to the M1 site, andnegative for the binding of the activating cations to the M3site ... activity, in the presence of a high Mg2+concentration, is probably dueto Mg2+binding to the zinc binding sites (M2 and M1).It appears that in contrast to the binding of Zn2+to the second ... enhancing the conformational change in path C,and enabling a conformational change in path A, therebyincreasing the rate of both cycles. In reaction path A, binding of Mg2+to subunit 2 inducesa...

Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx

... nucleolin ⁄ C23 in oxidative stress- induced apoptosis,but whether nucleolin ⁄ C23 participates in Hsp70-medi-ated protection against H2O2-induced apoptosis is notclear. In the present investigation, ... fromneonatal Wistar rats (1–3 days after birth) were removed,minced and trypsinized at 37 °C with gentle stirring in D-Hanks buffer containing 0.1% trypsin (Gibco, Rockville,MD, USA). The cells were then ... points as early as 2–4 h after H2O2treatment, this smaller protein fragmentappeared in the Hsp70-overexpressed cells at the 8 htime point (Fig. 2A,B). Overall, the change in nucleo-lin...

Tài liệu Báo cáo khoa học: Osmotic stress sensing and signaling in ﬁshes doc

... cascades, mitogen-activated protein kinasekinase kinase 7 interacting protein 2 (TAK 1 bindingprotein 2 ¼ TAB 2), as an IEG during hyperosmotic stress in tilapia gill epithelium [26]. This gene istransiently ... rapidly (within 2 h) induced byhyperosmotic stress, indicating a role of this mitogen-activated protein kinase kinase kinase 7 interactingprotein for osmosensory signal transduction in ﬁsh.14-3-3 ... response. The acute-phase response takesplace in the order of minutes to hours and involvesmany hormones, including arginine vasopressin, angio-tensin II, natriuretic peptides, vasoactive intestinal...

Tài liệu Báo cáo khoa học: ER stress and diseases docx

... stress [161], sug-gesting that these proteins are involved in ER stress- speciﬁc apoptosis.ATF6 is also involved in the apoptotic process dur-ing myogenesis. In differentiating myoblast, the ... UCH-L1ubiquitinates unfolded proteins and might be involved in ERAD [203]. These ﬁndings strongly suggest the involvement of ER stress in Parkinson’s disease. In addition, there are several other reports ... isomerasebelonging to the FKBP family. These ER chaperonesare involved in the general folding process of secretoryproteins.Calnexin and calreticulin are ER chaperones specif-ically involved in the folding...

Tài liệu Báo cáo khoa học: "word stress from spelling" ppt

... would be stressed using either the rules of the the language that it was borrowed from or the rules of the language that it was borrowed into. But neither the rules of Japanese nor the rules ... 32020103 The strength of these constraints will help make up for the fact that the mapping from orthography to weight is usually underdetermined, In terms of information theory, about half of the ... cloud (even after stripping off the final consonant). Thus, the stress of torment is either "31" or "13" stress depending on whether is has 0 or I extrametricai final syllables:"...

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

... a conserved DNA-binding motifknown as the Doublesex- and Mab-3-related (DM)domain. Being a noncanonical cysteine-rich DNA-binding motif, this domain has two highly intertwinedfinger structures ... at higher levels in testes than ovaries. The deep interest in Dmrt1 in the field of sex deter-mination in fish came with the discovery of a dmrt1homologue on the Y chromosome of the fish medaka(Oryzias ... chelate one zinc ion each, andbinds to the minor groove of the DNA [6]. Dmrts wereoriginally described to play important roles during sexdetermination in flies and worms by regulating severalaspects...

Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... metal-binding siteat the interface of the two domains, which consistsof four side chains: two (His31 and His79) from the N-terminal domain and two (Asp165 and His169) from the C-terminal domain ... attributed to the Mn or Fe ions incorporated into the enzyme as it accumulated in the E. coli cells. Indeed, the activity of the apo-enzyme was signiﬁcantly lowerthan the metal-containing enzyme.Metal ... grouped into fourclasses according to their metal cofactors: copper andzinc-containing SOD (Cu,Zn-SOD), iron-containingSOD (Fe-SOD), manganese-containing SOD (Mn-SOD) and nickel-containing SOD...

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