Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx
Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx
... with the gadolinium ions if they get through the channel. The affinity of the Gd3+compared to the EGTA is a million-fold larger than that of the Ca2+Fig. 6. Effect of gadolinium on the calcium ... 0.42.Discussion The effect of Gd3+was investigated on the function of SR Ca2+ release channel ⁄ ryanodine receptor complex.When the [3H ]ryanodine- binding was examined as the function of the gadolinium concentration ... cal-cium released. The effect of 5 lm gadolinium on the [3H ]ryanodine binding to the HSR was investigated atdifferent ryanodine concentrations. Gadolinium (5 lm)Table 1. The effect of cis gadolinium...
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Tài liệu Báo cáo khoa học: "Names and Similarities on the Web: Fact Extraction in the Fast Lane" ppt
... separately for the beginning of the first (left) and end of the sec-ond (right) phrases of the candidate fact. For gen-erality, the computation relies only on the part- of- speech tags of the current ... distinguish the quality of extractionpatterns based, for instance, only on the percent-age of the seed set that they extract. The secondreason is the noisy nature of the Web. A substan-tial number of ... consecutiveoccurrences of the part -of- speech tag Pi. The se-quence [P1P2 Pn] must be exactly the sequence of part of speech tags from the right side of one of the seed facts. The point where the sequence...
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Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy pdf
... Dicer knockdown on the silencing efficacy of mismatched siRNAsWe hypothesized that the reduction in the function of the mismatched siRNAs was a consequence of impaired interactions with TRBP and ... essentially the same silenc-ing capacity as in the presence of TRBP, actuallybecoming the most active of all the siRNAs under theseconditions (Fig. 2A). In contrast, after knockdown of Dicer, only the ... the band wasshifted in the presence of the Dicer antibody but not the other antibodies.We also wished to confirm the location of anyTRBP-containing bands, if these could be visualized. Inthe...
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Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx
... the closed conformation. The only other P-loop move-ments that have been observed in PTPs are a result of oxidation of the catalytic cysteine.Sensitivity of PhyAsr to oxidation The low pKa of the ... closed P-loopconformation is stable over a broad ionic strengthrange.Structure of PhyAsr upon oxidation of the catalytic cysteineA systematic comparison of the open P-loop confor-mation in PhyAsr ... Bank:2PT0).AR258C252BR258C252Fig. 1. (A) Conformation of the P-loop at low ionic strength in the absence of ligand. The P-loop is observed in the catalytically com-petent conformation. The electron density from a sigma-weighted2Fo)Fcmap...
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
... demonstrated the essential role of this region in the transcription of the Ig-b gene. Deletion of region III decreased the expres-sion of Ig-b mRNA to 40% of the expression in prede-letion cells ... deletion (16 kb Del) in one allele of the Ig-b locus (Fig. 1). Introduction of the 16 kb Delconstruct into DT40 ⁄ Cre cells resulted in two deletionclones. In one of these two clones, the Bsr ... of the South-ern hybridization. Position of the probes, the size and position of restriction fragments hybridizable with the probe, and exon ⁄ introns areshown as in Fig. 2A. Positions of the...
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Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf
... under low ionic strength conditions [8,44].However, this effect is not seen in the kinetics of the MA/CA hydrolysis. In the high ionic strength of the assays the dimerization is strengthened as ... PRinhibitor therapy, soon after the appearance of one (or afew) critical PR mutations, therefore we have characterized the effect of single protease mutations in response to Gagcleavage site mutations. ... to Val mutation, without the appearance of P3 Argmutation [10]. In these mutants the positive effect of P3 Argis offset due to the loss of favorable hydrophobic interactionwith the smaller...
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Tài liệu Báo cáo khoa học: "Effect of Cross-Language IR in Bilingual Lexicon Acquisition from Comparable Corpora" pot
... translation knowledgein order for it to be used in the real world situ-ation. One limitation of the corpus-based trans-lation knowledge acquisition approach is that the techniques of translation ... reduction with the help of cross-language retrieval of relevant texts is quiteeffective in improving the performance of preciseestimation of bilingual term correspondences.2 Acquisition of Bilingual ... bounds and the upperbound of the number of constituent words. Then,based on the contingency table of co-occurrencefrequencies of tE and t j below, we estimate bilin-gual term correspondences...
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Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc
... thetase to esterify the 13cROL generated in the reac-tion. Therefore, 13cROL is accumulated in the absence of LRAT in the reaction (Fig. S3B).Under the in vitro assay conditions of the ... substrate under the same reaction conditionsand extraction procedures. The peak of each retinoid iso-mer was identified based on its characteristic retention timeand the absorption spectrum of each ... that the enzy-matic activity of RPE65c is iron-dependent.Characterization of the kinetic parameters of the enzymatic activity of zebrafish RPE65cTo determine the steady-state kinetics of the...
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Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
... position. A comparison of the structure of the unli-ganded cathepsin B with the structure of the proenzyme, its complexes withchagasin and stefin A shows that the magnitude of the shift of the ... adopt a variety of con-formations, whereas the rest of the structure of cathep-sin B appears to be rigid.A comparison of the interaction constants of the binding of chagasin (Ki= 0.93 nm [25]) ... site, the farther away the occluding loop residues areshifted. As seen in the tetragonal form of the cathepsinB chagasin complex (3CBK), the depth of the binding of inhibitor as well as the shift...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
... included in the pub-lished alanine scanning mutagenesis study of FVIIa[13], and investigated the effects of the mutation on the enzymatic maturation of FVIIa and on the response of FVIIa to ... two of the components of the invisible scaffold supporting the active conformation. One bond participates in stabil-ization of the 170 loop while the other connects activa-tion loops 2 and ... Lys341(192)–Gly342(193) peptide bond, which constitutes part of the oxyanion hole and the rim of the S1 pocket, mayrotate 180 °C depending on the type of inhibitorbound. Similarly, rotation of the Ser363(214)–Trp364(215)...
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