Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc

... The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase 1What is the role of quinonoid intermediates?Nicolai G. Faleev1, Tatyana V. Demidkina2, Marina ... deﬁnesautomatically the positions of the a-proton and the sidechain of any bound amino ac id. The lability of the a-proton observed for a large number of amino acids [5] under the action of TPL gives ... the best candidate for t he binding of the a-carboxylate group of the s ubstrate, when the external aldimine is formed. The anchoring of a-carboxylateand a -amino group in the external aldimine...

Tài liệu Báo cáo khoa học: "The Impact of Query Reﬁnement in the Web People Search Task" docx

... extracted several types of features from eachdocument. First, we applied a simple preprocess-ing to the HTML documents in the corpus, con-verting them to plain text and tokenizing. Then,we extracted ... while avoiding con-fusion with other people sharing the same name.But the utility of clustering is more obvious for re-call oriented queries, where the goal is to mine the web for information ... person. In a typicalhiring process, for instance, candidates are eval-uated not only according to their cv, but also ac-cording to their web proﬁle, i.e. information aboutthem available in the...

Tài liệu Báo cáo khoa học: "The Use of Ooject-Special Knowledge in Natural Language Processing" doc

... [3]. The Functioning of these demons will be Illustrated below. 3.1 THE INITIAL ANALXSIS In the processing of the sentence "Jo~n opened the bottle so he could pour the wine," the ... stereotyplc knowledge of objects into the conceptual analysis of text. By encoding information in OP descriptions, we were able to increase the interpretive power of the analyzer in order to handle ... updating memory by adding the new state information to the token in the ACTOR slot of the state description. Thus the bottle token is updated to include the gtven CONNECTOR description. For the...

Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt

... acts in the third step of leucine degradation and the sku mutant accumulates branched-chain amino acids in haemolymph, thismutant may be useful in the investigation of unique branched-chain amino acid ... strainsrevealed the presence of a single point mutation in 1337 nucleotides of BmIVD. In the sku mutant, the 1127th guanine from the start codon was substituted by thymine and none of the other sites ... neigh-bouring monomer in the tetramer. By contrast, the side chain of the mutated residue (Val376) pointstoward the inside of the helix–loop–helix structure.Consequently, the side-chain atoms of Val376...

Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx

... site(NXS ⁄ T), found in PmaHc2 at position Asn334, isconserved in all subunit types (Hc1 and Hc2) with the exception of PmaHc1. An insertion of nine amino acids in PamHc2 starting at amino acid 435 ... into the hemolymph [23] in all subunits except HmeHc1(Fig. 1). Therefore, the native proteins consist of 650–670 amino acids with predicted molecular masses of 75.43–79.59 kDa. The amino acid ... with genedoc 2.7 [41]. The tools provided with the ExPASy Molecular BiologyServer of the Swiss Institute of Bioinformatics (http://www.expasy.org) were used for the analyses of DNA and amino acid...

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... interact with a number of functionalgroups, including the aromatic side chains of some amino acids, through a stacking mechanism [42]. The interaction of arginine with aromatic amino acids of aB-crystallin ... analysis of the puriﬁed proteins indicated thatthey contained < 5% contaminating proteins. The concen-trations of proteins used in these studies were determined by spectrophotometric methods using ... no in uence of the additiveon the chaperone activity of aB-crystallin (i.e. the effect of the additive on the aggregation of the target protein is inde-pendent and different from that of the...

Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin ﬁbre pptx

... nucleosomes in the mainpeak, indicates that crosslinking is almost complete in the middle of the ﬁbre, but some of the end-nucleo-somes are not crosslinked to the rest and thereforemust originate ... chromatin in which the presence of linker his-tone is questionable. Furthermore, the presence of alloligomers, with dimers up to the half the size of the original samples after digestion of the linkers, ... constraintsimposed by the length of the linker DNA on the tilts of the nucleosomes, as discussed elsewhere [24].Dorigo et al. [14] studied the sequentiallity of the nucleosomes in the ﬁbre using...

Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf

... chemokines stimu-lated mainly by in ammatory cytokines, including IL-1b, TNF-a andIFN-c. (B) Chemokines expressed in the joint recruit leukocytes into the joints. In addition to functioning in ... polyarticular joint dis-ease that primarily affects the small joints of the hands and feet. The in ammatory process is characterized by in ltration of in ammatory cellsinto the joints, leading to proliferation ... aG-protein that transduces the intracellular signal. The two major subclasses include the CC chemokines(where the cysteines are neighboring) and the CXCchemokines (where the cysteines are...

Tài liệu Báo cáo khoa học: The stereochemistry of benzo[a]pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases pptx

... 5-methylcytosine was introducedinto one of the strands of the recognition site instead of the target cytosine. The melting curves of the hemi-methylated X+CG ⁄ CGM and GCX+⁄ CGM duplexescontaining ... M.HhaIconsists of two domains, the large domain containing the S-adenosyl-l-methionine (AdoMet) binding siteand the catalytic center, and the small domain contain-ing the target recognition domain (Fig. ... large increase in ﬂuorescence in the case of the complex of M.SssIwith the GCY+⁄ CGM duplex containing the (+)-trans adduct in the CpG site may be caused by diminished quenching by the target...

Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx

... phosphorylation of proteinsinvolved in the trafﬁcking of the receptor, includingc-Cbl, could account for its intracellular retention. By contrast, TDI mutations in the ECD or disruption of the termination ... Based on the cDNAsequence of FGFR3 including the 5¢-UTR, the X807Rmutation that eliminates the regular stop codon wasexpected to produce an elongated protein of 947 amino acids and containing a ... through the Golgi network.This resulted in defective expression of the mature isoform at the cell sur-face. Normal processing was rescued by tyrosine kinase inhibitor treatment.Internalization of...

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