Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt
Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc
... EC, endothelial cell; FGF, fibroblast growth factor; HIF, hypoxia-inducible factor; PlGF, placenta growth factor; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor ... dependent on the vascular endothelial growth fac-tor ⁄ vascular endothelial growth factor receptor(VEGF ⁄ VEGFR) system [1,2], and the further devel-opment of blood vessels in various tissues and organs,including ... (2003) The biologyof VEGF and its receptors. Nat Med 9, 669–679.2 Shibuya M (2008) Vascular endothelial growth factor- dependent and -independent regulation of angiogenesis.BMB Rep 41 , 278–286.3...
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Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt
... Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms Eric Sulpice1, ... VEGF, and compared the mechanisms by which PF -4 i nhibits the DNA synthesis induced by VEGF165 and VEGF121. The DNA synthesis induced by VEGF165 and VEGF121was strongly inhibited b y PF -4 (10 ... angiogenic factors, in cluding fibroblast growth factors (FGFs), platelet- derived growth factor B(PDGF-B) and vascular endothelial growth factor (VEGF)[1,2]. These factors are counterbalanced by inhibitorymolecules...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
... the vicinity of the S1 pocket [11, 34] , in the first part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8,35], areasthat are stabilized by TF [9,25,26]. The ... from the FVIIa molecule that is presentin the active conformation of both the free and TF-bound form, rather than shifting the equilibriumbetween the zymogen-like and active conformations, and ... active site region and the S1pocket, whereas the intramolecular connections, forinstance between the TF-binding region and the activesite and between the TF-binding region and the activa-tion...
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Tài liệu Báo cáo khoa học: Functional effects of deleting the coiled-coil motif in Escherichia coli elongation factor Ts pptx
... mgÆmL)1poly(U). The factor mix contained 8.0 lM[ 14 C]Phe-tRNAPhe (44 c.p.m.per pmol), 112 nMactive EF-G, 40 nMactive EF-Tu and 0–8.0 nMEF-Ts. The ribosome mix and the factor mix wereincubated ... D 42 0value of the culture at the interception point between the exponential and the Ôstarvation phaseÕ of growth, is 78% of the point of growth inhibition of UY211 (D 42 0¼ 0.60). The point of growth inhibition ... Duringexponential growth, the (p)ppGpp basal levels weresimilar in both stains (UY211 D 42 0< 0.575; GRd.tsf:D 42 0< 0 .47 5). At the points of growth inhibition, ppGpp and pppGpp appear both in UY211 and...
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Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc
... followed by 35 cycles of 94 °Cfor 30 s, 58 °C for 30 s and 72 °C for 30 s. The sizes of the PCR products were confirmed by 2.0% agarose gel electro-phoresis and further confirmed by the direct ... standard.Isomerohydrolase activity was calculated from the area of the 11cROL and 13cROL peaks and expressed as the mean ± SD of three independent measurements.Retinal cell dissociation The ... the entire thicknessof the inner retina. The Mu¨ller cell constitutes an ana-tomical link between the retinal neurones and supportstheir activities by exchanging molecules between the other...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... elastase, MIP-2, and TLR -4 expression during human and experimentalsepsis. Shock 23, 39 44 .30 Chaluvadi MR, Nyagode BA, Kinloch RD & MorganET (2009) TLR4 -dependent and -independent regula-tion ... showed a markeddecline at 24 h after CLP, and the reduction was atten-uated by GdCl3(Fig. 4) .Hepatic TLR2 and TLR4 protein expression The hepatic level of TLR2 and TLR4 protein expres-sion showed ... with the method previously described by Chomczynski and Sacchi [44 ]. Reverse transcription of total RNA was performed forsynthesis of the first strand of cDNA using the oligo12–18pri-mer and...
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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc
... deprivation- induced apoptosis. J Immunol 177, 244 1– 245 1. 4 Alvarado-Kristensson M, Melander F, Leandersson K,Ro¨nnstrand L, Wernstedt C & Andersson T (20 04) p38-MAPK signals survival by phosphorylation ... Ser112, Ser136 and Ser155 [86]. The dissociation of Bax and Bad from 14- 3-3 is pro-moted by JNK via phosphorylation of 14- 3-3 atSer1 84; this reduces the affinity of 14- 3-3 for Bax and Bad and translocation ... PPPP1591211631 84 PPPMcl-1BaxP1211631 84 PPMcl-1BaxP1 84 Mcl-1BaxP1 84 BaxP1 84 Bcl-xLBax136112155PPPBad 14- 3-31 84 BadP 14 -3-3PPPCaspase-9PP3 64 ActivationCleavage 46 5397PPPCaspase-8150Caspase-3PCleavageActivationPCaspase-3Endo...
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Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf
... FEBSsecond site). The measured enthalpy is the sum of twoterms: the reaction enthalpy, independent of the bufferused in the experiment, and another term representing the contribution of the proton ... binding affinity by 100-fold and the lifespan of the complex by 10-fold, as judged by koff. The physiologicalchaperone cycle probably consists of the rapid bindingof the N-terminus of the partner, ... (Fig. 4C). The decrease in some of the free state resonances and the appearance of new resonances upon complexformation indicated a slow exchange on the NMRtimescale between the free and the...
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Tài liệu Báo cáo khoa học: An autoinhibitory effect of the homothorax domain of Meis2 ppt
... splicingaround the 5¢-end of exon 6 of Meis2 and Meis3 was tested by RT-PCR. The positions of molecular mass markers are shown to the left, and the size in base pairs of the products to the right (the Meis2 ... analyzed by western blot (WB) with a GBD antibody. The specificfull-length bands are indicated by arrows. The numbers below the lanes correspond to the numbered constructs in (E) and Figure 4 (F). The positions ... PBX1 (uniprotkb:P4 042 4 )by anti tag coimmunoprecipitation (MI:0007)lMINT-7718110: Meis2e (uniprotkb:O 147 70-5) physically interacts (MI:0915) with PBX1(uniprotkb:P4 042 4)byanti tag coimmunoprecipitation...
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Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
... bond between the stefin A A49amide and cathepsin B G 24 carbonyl. The binding ofthis loop is further stabilized by a hydrogen bondbetween the stefin A N52 side chain amide and the cathepsin B S25 ... activ-ity, nor the inhibition of the enzyme by their endoge-nous protein inhibitors cystatins and stefins [21].A further step in understanding of these mechanisms was provided by the crystal structures ... B and H and the center of CA atoms of stefins in the structures of both complexes. The average distance is 23 .4 A˚, whichis the same for both enzymes (Table 1). The compari-son shows that the...
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Từ khóa: Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ