... activation and plasma membrane localization of the fusion constructare dependent on phosphatidylinositol 3-kinase signal-ing, and that ITK–SYK phosphorylates the adapterproteins SLP-76 and ... capacity, membrane localization and phosphorylation of key residues?Comparison between the activation of ITK–SYK and BTK–SYKTo determine its activation capacity, we constructed the corresponding ... development and main-tenance of hematological malignancies [67]. Moreover,as a result of chromosomal translocation, a chimera,consisting of the dimerizing TEL protein and SYK,was formed and has been...