... near the N- and C-termini of the linkers: this suggests thata mobile connection with both the catalytic domainand the binding module is required for the function of the nanomachine. Furthermore, ... covering the face of the aromatic ring [25].Alternatively, the ring may sterically disfavor extensivebending in this region, which could result in unwanted interactions between the linker and the ... structure, away from the water mole-cules in the solvent. During the process of folding, aswell as in its final fold, the stability of the molecularedifice is further modulated by interactions betweengroups...