... 2009)doi:10.1111/j.1742-4658.2009.07314.x The mature capsid of human immunodeficiency virus, HIV-1, is formed by the assembly of copies of a capsid protein (CA). The C-terminal domain of CA, CTD, is able to homodimerize and most of the ... for the whole CA has the sequence IPVGEIYKRW, whichcorresponds to the a-helix 7 of NTD. This region is important for the formation of CA hexamers [6]; there-fore, this peptide could inhibit the ... that the higher the helicity, the higher the inhibition of assembly. The affinity of NAYD-1 for CTD is the largest reported to date, withvalues close to 1 lm. The difference in affinity fromthe...