Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc
Tài liệu Báo cáo khoa học: Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 pdf
... effect of increasing concen-trations of native and oxidized elafin and trappin onthe activity of a constant concentration of NE and Fig. 1. Inhibition of neutrophil elastase (NE) and proteinase ... residues (M25 and M51 for elafin, and M63 and M89 for trappin). M25 and M63 are the P1¢residues of the inhibitors’ active centers. Mass spectro-metry of the two proteins oxidized by N-chlorosuccini-mide ... highly con-centrated substrate solutions and following the hydro-lysis of substrate as a function of time. The complexesformed of NE and native or N-chlorosuccinimide-oxi-dized elafin and trappin...
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Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc
... compilation ª 2007 FEBS Binding of N- and C-terminal anti -prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse Thorsten ... for human, sheep, cattle and mouse. The calculation is composed of signals from the N-ter-minal binding antibodies SAF34, P4 and 8G8 or the C-terminal bind-ing antibodies 6H4, SAF60, SAF70 and ... the N-terminally truncatedform. The distribution of the signal intensities of theFig. 1. Sequence alignment of prion proteins of humans, sheep, cattle and mice. Recognition sites of the antibodies...
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Tài liệu Báo cáo khoa học: Binding of ligands originates small perturbations on the microscopic thermodynamic properties of a multicentre redox protein pptx
... measure-ments of the reduction potentials of proteins involvedin complexes have been reported [5–7], but the effect of partner binding on the microscopic properties of theredox centres in proteins ... the binding of Zn-rubredoxin.Overall, the two sets of results reported show thatphosphate binding and docking with the Zn-rubredox-in has a very limited effect on the redox properties of the ... Lisboa, Portugal3 School of Chemistry, University of Southampton, UKThe structural aspects of protein complexes havereceived considerable attention and several experimen-tal and computational methods...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... user of long-chain fattyacids making a brain-specific isoform intriguing.CPT1c was identified and cloned from in silicosequences as a highly homologous member of theCPT1 class of enzymes and ... directly uponendocrine signals, although endocrine factors canimpinge on its activity. Thus, the activity of ACC isan indicator of energy surplus and is thought to beone of the mechanisms ... entry of fatty acid into mitochon-dria. Thus, the steady-state level of malonyl-CoA inthese tissues is determined by the relative activities of ACC and malonyl-CoA decarboxylase.Role of the...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... thestructures of PSs from E. coli and M. tuberculosis.Structural analysesAnalysis of the sites of substrate binding from NMR data, and structural comparison of the E. coli, M. tuberculosis and A. ... suggests that binding of pan-toate and ATP preserves the dimer symmetry in solu-tion. In an effort to unambiguously identify and understand the nature of binding of pantoate at theATP -binding site, ... Confor-mation of polypeptides and proteins. Adv Protein Chem23, 283–438.34 Panigrahi SK & Desiraju GR (2007) Strong and weakhydrogen bonds in the protein ligand interface. Proteins Struct Funct...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
... study of FVIIa[13], and investigated the effects of the mutation onthe enzymatic maturation of FVIIa and on theresponse of FVIIa to TF.Our measurements, in both the presence and absence of TF, ... subsites, of ABFig. 5. Structure of FVIIa and model of G372A-FVIIa. (A) Energy-minimized structure of FVIIa. Representation of the part of FVIIadiscussed in the text (based on Protein Data ... functional defect of G372A-FVIIa was, if anything, smaller in the presence of TF,which suggests that the allosteric effect of TF, influenc-ing burial of the N-terminus, and the extent of cata-lytic...
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Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc
... the membrane localization of proteins will facilitate the formation of protein com-plexes and increase reaction rates [35]. To mimic thein vivo situation, Src and other proteins can be embed-ded ... loops and occur at constant activities of Src inhibitors and activators, such as C-terminal Src kinase and receptor-type protein tyrosine phosphatases. We demonstrate that C-terminal Srckinase and ... CellBiol 9, 905–914.55 Sandilands E, Brunton VG & Frame MC (2007) Themembrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome...
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Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf
... purification of tissue inhibitor of metallo-proteinases-2 from its 72 kDa progelatinase complex.Demonstration of the biochemical similarities of tissueinhibitor of metalloproteinases-2 and tissue ... Loennechen1 and Jan-Olof Winberg21 Department of Pharmacy, University of Tromsø, Norway2 Department of Medical Biochemistry, University of Tromsø, Norway3 School of Pharmacy, University of Oslo, ... placeintracellularly or extracellularly, surface proteins of cells attached to plastic and 2D collagen were labelledwith biotin and removed as described in Materials and methods. The unlabelled intracellular...
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Tài liệu Báo cáo khoa học: Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37Rv pdf
... coordi-nating proteins. Iron–sulfur clusters are one of themost ancient and versatile cofactors of several impor-tant class of proteins and have been implicated in vari-ety of functions [29,30]. Iron and ... scavenging of freeradicals and the reactivation of degenerated proteins during infection by a family of proteins named ‘thio-redoxins’ is one of the elegant mechanisms of defense and self-sustenance ... availableinformation on WhiB proteins demands careful investi-gation of the biochemical and biophysical properties of each.Mycobacterial WhiB proteins have 22–67% identitywith WhiB protein of S. coelicolor...
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Tài liệu Báo cáo khoa học: Substrate specificity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola ppt
... values of 60 kDa and 120 kDa (Fig. 3B). Similarly, the purified protein BHAb was eluted from Superdex 200 (data not shown)Fig. 2. Effect of camalexin and 3-phenylindole on the activity of BH from ... suggest that BHs from L. maculans and A. brassicicola belong to the amidase-signature super-family of proteins that contain the Ser ⁄ Ser ⁄ Lys triadactive site. Proteins of the amidase-signature ... quantities of protein utilizingthe principle of protein- dye -binding. Anal Biochem 72,248–254.Supporting informationThe following supplementary material is available:Fig. S1. Sequence alignments of...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansThơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt nam