... translational initiation factor 2; ER, endoplasmic reticulum; ERAD, ER- associateddegradation; ERdj, ER dnaJ; ERO1, ER oxidoreductin; ERp72, ER protein 72; ERSE, ER stress response element; FKBP13, ... [144,145]. During ER stress, Bax and Bak oligomerize and activate caspase-12.Interestingly, Bax and Bak associate with IRE1a and modulate IRE1a function during ER stress [146]. Bax and Bak are required ... 165–172.195 Unterberger U, Hoftberger R, Gelpi E, Flicker H,Budka H & Voigtlander T (2006) Endoplasmic reticu-lum stress features are prominent in Alzheimer diseasebut not in prion diseases...