... occur-ring in many different combinations are the P-loopnucleotide triphosphate hydrolase domain, the epider-mal growth factor (EGF) domain, the SH3 domain,the P-kinase domain and the domains involved ... mostly gene fusion and domain loss and, prob-ably to a lesser extent, domain shuffling of exons and recombination [13–17].While the emergence of domain combinations is welldocumented [4,6,7,18–21], ... domain deletions are more com-mon at either of the protein termini, and that theiroccurrence is slightly higher at one of the termini,depending on the number of domains in the proteinand...