... TF, tissue factor; TFPI, tissue factor pathway inhibitor; I, inhibitor; VII, factor VII; VIIa, factor VIIa; VIIa–TF, the complexof factor VIIa and tissue factor; E, enzyme; X, factor X; S, substrate;Xa, ... Hemker, H.C. &Lindhout, T. (1999) Inhibition of tissue- factor- factor VIIa-cata-lysed factor X activation by factor Xa -tissue factor pathway inhibitor. J. Biol. Chem. 274, 28225–28232.22. Tikhonov, ... K.G. (1997) Regulation of tissue factor initiated thrombin generation by the stoichiometric inhibitors tissue factor pathway inhibitor, antithrombin-III, and heparincofactor-II. J. Biol. Chem....