... processing of the basal and elevatedamounts of procaspase-8 in both control and IFN-trea-ted cells and there was an approximately two-foldincrease in the amount of the p18 large subunit of activecaspase-8 ... combination of IFNa and TRAIL,relative to TRAIL alone. In view of the cleavage of caspase substrates such asBID and PARP, the effect of IFNa and TRAIL onthe DNA content of MCF-7 cells was also ... Shigeno M, Nako K, Ichikawa T, Suzuki K, Kawakami A, Abiru S, Miyazoe S, Nakagawa Y, Ishikawa H,Hamasaki K et al. (2003) Interferon -a sensitizes humanhepatoma cells to TRAIL-induced apoptosis...