... 2008)doi:10.1111/j.1742-4658.2008.06347.xStrategies for the chemical construction of synthetic proteins with preciselypositioned post-translational modifications or their mimics offer a powerfulmethod for dissecting the complexity of functional ... consequence of the lack of direct genetic control of their biosynthesis, natural PTMs vary in site and level of incorporation, leading to mixtures of modified pro-teins that may differ in function. ... ARTICLE Chemical approaches to mapping the function of post-translational modifications David P. Gamblin, Sander I. van Kasteren, Justin M. Chalker and Benjamin G. DavisChemistry Research Laboratory,...