... Schapira AH (2008) Mitochondria in the aetiology andpathogenesis of Parkinson’s disease. Lancet Neurol 7,97–109.4 Hayashi S, Wakabayashi K, Ishikawa A, Nagai H, Sai-to M, Maruyama M, Takahashi ... stress conditions. Specifically, this association is mediated by pathogenic DJ-1 mutations and oxidativestress [76]. These data suggest a link DJ-1 and Parkin in a common pathway in mammals. A described ... LRRK2 and ATP1 3A2 cause autosomal-dominant forms of parkinsonism.Mutations in the genes encoding Parkin, DJ-1 andPINK1 all cause autosomal-recessive parkinsonism ofearly onset and are the focus...