Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the speciﬁcity and relative binding energy of RNA-binding proteins ppt

... the performance of the potential will only increase with the size of the structural database and as terms areadded to the model to account for protein and RNAintra-molecular interactions that are ... knowledge-based potential function predicts the speciﬁcity and relative binding energy of RNA -binding proteins Suxin Zheng1,*, Timothy A. Robertson2,* and Gabriele Varani1,21 Department of Chemistry, ... complexes). Weanticipate that the increasing availability of protein–RNA structures, together with the availability of dataon speciﬁcity, will further improve the performance of the knowledge-based...

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... biology approach for the analysis of carbohydrate dynamics during acclimation to lowtemperature in Arabidopsis thalianaThomas Na¨gele, Benjamin A. Kandel*, Sabine Frana*, Meike Meißner and Arnd ... simulation A mathematical model was developed, representing centralcarbohydrate metabolism in leaves of A. thaliana. The model was based on the following system of ordinary dif-ferential equations ... organs or metabolic pathways other than carbo-hydrate pathways was calculated as the differencebetween net carbon uptake and changes in cellular car-bohydrate content. The resulting surplus of...

Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

... l-dopa as cofactor toeliminate the characteristic lag period of tyrosinases[8,20,21]. Figure 3 shows the rate of TH activity as a function of the concentration of l-dopa cofactor addedto the assay ... wasadded for the standard TH assay, and 0.02% SDS wasadded for DO activity. For dopa titration, 50 lL10mmsodium periodate was added, and the increase in A 475immediately determined. A small ... The most reliable way of exploring this is comparison of crystal structure data. The only data so far available are for sweet potato(Ipomoea batata) catechol oxidase [26]. The catalyticcopper...

Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

... to pain and was effective inalleviating chronic pain and accelerating functional recoveryin an animal model of neuropathy. These data are inagreement with an important role of nAChRs in painperception, ... orthat the functional properties of the nAChR are modiﬁed in a cell-speciﬁc way. The fact that an anti -a7 mAb selectivelyinhibited the a- BTX-sensitive current in intracardiac gangliaargues against ... mammalian tissues. A mammalian homologue of the avian a8 subunit has not been found [2,3,9].Subunit assembly of neuronal nAChRs The a7 , a8 anda9 subunits represent a subclass of neuronalnAChRs...

Tài liệu Báo cáo khoa học: "A Uniﬁed Syntactic Model for Parsing Fluent and Disﬂuent Speech∗" ppt

... is the fact that thereis often a good deal of overlap in words between the reparandum and the alteration, as speakers maytrace back several words when restarting after an er-ror. For instance, ... use in a specialrepair grammar, which not only reduces the amount of available training data, but violates our intuitionthat most reparanda are ﬂuent up until the actual editoccurs. The right ... instance, in the repair a ﬂight to Boston,uh, I mean, to Denver on Friday , there is an exactmatch of the word ‘to’ between reparandum and re-pair, and a part of speech match between the words‘Boston’...

Tài liệu Báo cáo khoa học: "A Joint Statistical Model for Simultaneous Word Spacing and Spelling Error Correction for Korean" pdf

... probabilities and Eojeol transition probabilities to create spelling correction candidates. Candidates are increased in number by inserting the blank cha-racters on the created candidates, ... several advantages. Since an Eumjeol is a combination of 3 Jasos, the number of all possible Eumjeols is much larger than that of all possible Jasos. In other words, Jaso-based language model ... er-rors simultaneously. Using Eojeol transi-tion pattern dictionary and statistical data such as Eumjeol n-gram and Jaso transition probabilities, the algorithm minimizes the usage of huge word...

Tài liệu Báo cáo khoa học: "A HARDWARE ALGORITHM FOR HIGH SPEED MORPHEME EXTRACTION AND ITS IMPLEMENTATION" pptx

... posed of the 2nd candidate at the 1st position, the 1st candidate at the 2nd position and the 3rd candidate at the 3rd position. The architecture described in the previous section can be easily ... The other dimension corresponds to the candidate level. Candidates on the same level form one stream. For example, in Fig. 6 (a) , the character at the 3rd position has three candidates: the ... 1-1, Miyazaki 4-chome, Miyamae-ku, Kawasaki City, Kanagawa 213, Japan (fuku@tsl.cl.nec.co.jp, ohyama~tsl.cl.nec.co.jp, miya@tsl.cl.nec.co.jp) ABSTRACT This paper describes a new hardware algorithm...

Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx

... information for the functional analysis of plant DEVH box RNA helicases, and suggest that AtHELPS, as an impor-tant negative regulator, plays a role in K+deprivation stress.AbbreviationsABA, abscisic ... Temporal and spatial expression of AtHELPS. (A) The relative expression of the AtHELPS gene in shoots and roots at different devel-opmental stages, as revealed by real-time quantitative PCR analysis. ... glucuronide of the transgenic plants. The average GUS activity was obtained from at least ﬁve indepen-dent transformants, and each assay was repeated three times.RNA extractionFor RNA isolation, the...

Tài liệu Báo cáo khoa học: a-enolase: a promising therapeutic and diagnostic tumor target ppt

... Ricerca SanitariaFinalizzata, Ricerca Sanitaria Applicata; RibovaxBiotechnologies (Geneva, Switzerland) and FondazioneItaliana Ricerca sul Cancro (FIRC).References1 Pancholi V (2001) Multifunctional ... incervix and colon cancer, leukemia, normal pancreaticducts and tumoral pancreatic cells. Fourteen acetylatedlysine residues are common to leukemia, pancreaticcancer and normal pancreas, and one of ... Barbar-roja N, Gomez-Diaz C, Rodriguez-Ariza A, BuendiaP, Torres A & Velasco F (2006) Proteomic analysis of acute myeloid leukemia: identiﬁcation of potential earlybiomarkers and therapeutic targets....

Tài liệu Báo cáo khoa học: A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics ppt

... the dark gray area of the Venn diagram are thought to be relatively abundant in serum, and are primary candidates for further validation. Glycoproteinsfound in the pale gray area are secondary ... knowledge of human glycosylation,glycan structural analysis systems, the bioinformaticscapability and the databases that we have developedover the years, and animal models of aberrant glyco-sylation ... the dynamic mammalian glycome. Proc Natl Acad Sci USA104, 11534–11539.14 Tateno H, Uchiyama N, Kuno A, Togayachi A, SatoT, Narimatsu H & Hirabayashi J (2007) A novel strat-egy for mammalian...

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