... the ACT1 domain is insertedinto the ACT2 domain; and (c) two ACT domains,each from a different chain, interact to form an effec-tor-binding unit. The effector-binding unit of the ACT domain ... dimers in the asymmetricunit. A chain, magenta; B chain, yellow; C chain, cyan; D chain, green; E chain, brown;F chain, blue. (B) EF chain dimer.Crystal structures of regulatory subunit of Thr-sensitive ... change of the regulatory domaindimer upon Lys binding, resulting in the displacement of several residues responsible for catalytic function in the catalytic domain. The most distinct differencebetween...