... genetics and
epigenetics in Ras oncogenic signaling
There is a bilateral relationship between genetic and
epigenetic mechanisms in the activation of oncogenic
Ras signaling. Activation of K -Ras and ... 5235
REVIEW ARTICLE
DNA methylation-mediated nucleosome dynamics and
oncogenic Ras signaling
Insights from FAS, FAS ligand and RASSF1A
Samir K. Patra
1,
*...
... and HinfI for 3 h and recovered by
ethanol precipitation. The precipitated DNA was dissolved
in 3 lL of water and added into the ligation mixture
[100 ng each of landmark- and HinfI-adapter and ... in
other symbiotic and parasitic bacteria. These results suggest that DNA
adenine methylation may contribute to the establishment and ⁄ or mainten-
ance of symbiotic and parasit...
... DNA without any protein; lanes 2, 3
and 4 correspond to DNA complexes with p53(1–363), p73d and p73b, yielding retarded bands R
53
,R
73d
and R
73b
, respectively. In lanes 5–7,
the protein DNA ... one strand and two AG steps in the other. The
mdm2 target, whose interaction with p53 was most
strongly affected by DNA cis-platination, contains
GG, GGG and AG motifs in one stran...
... of
single-strand DNA (ssDNA) and assimilation of ssDNA
into homologous super-coiled duplex DNA. J Biol
Chem 276, 41906–41912.
10 Nara T, Hamada F, Namekawa S & Sakaguchi K (2001)
Strand exchange ... single
and double stranded DNA binding activity. Binding to
single stranded DNA stimulated a significant level
of DNA dependent ATPase activity. OsDmc1 also
showed renaturation of...
... aromatic side chain.
Modeling and molecular dynamics simulations
In order to address the possible conformations and
motions of the linkers, model building and molecular
dynamics simulations were ... linker peptides and the engi-
neering of size and composition variations in order to
address their function in activity, substrate binding
and structural dynamics.
Materials and...
... S-transferase
(GST)p, Ran 1 binding protein and C1q binding pro-
tein], related to cell signaling, apoptosis and cytoskele-
ton regulation (Fig. 2, insets; shaded versus white
bars). On the other hand, ... 2010 The Authors Journal compilation ª 2010 FEBS
31 Andersen SS (2000) Spindle assembly and the art of
regulating microtubule dynamics by MAPs and Stath-
min ⁄ Op18. Trends Cell...
... reveals a novel signaling cassette, dual usage in
ITAM signaling, and influence on development of the
Ly49 repertoire. Blood 112, 2869–2877.
151 Engels N, Wollscheid B & Wienands J (2001) Associa-
tion ... transmembrane ligand EphrinB1) led to
increased LAT phosphorylation and p44 ⁄ 42 and p38
MAPK activation [90]. This signalling pathway may
be essential in T cell–T cell costimul...
... progression and tumour angio-
genesis. Nat Rev Cancer 8, 632–645.
47 Klagsbrun M & Eichmann A (2005) A role for axon
guidance receptors and ligands in blood vessel develop-
ment and tumor angiogenesis. ... (e.g.
hypoxia-inducible factor and Src-suppressed C kinase substrate ⁄ AKAP12)
and soluble factors (e.g. vascular endothelial growth factor and angiopoie-
tin-1), as well as...
... cells and astrocytes, and
the tight junctions of vascular endothelial cells (ECs)
in the BBB are well organized with claudins and ZO-
proteins through a decrease in angiogenesis signaling
and an ... embryogenesis and adulthood, and
functions by binding with two tyrosine kinase recep-
tors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR ⁄ Flk-1),
Fig. 1. The VEGF–VEGFR system and the
inhib...
... neurovascu-
lar unit (Fig. 2). Loss of signaling between astrocytes
and endothelium alters tight junction homeostasis and
leads to BBB disruption. Perturbations in neuronal–
glial signaling lead to loss of ... that
angiogenesis may improve cerebral perfusion and func-
tion as part of a network repair.
The spatial and temporal dynamics of post-stroke
angiogenesis are complex and...