... The expression of T-bet has beenseen within a wide variety of tissues and cells in theGinbuna crucian carp [27] and, in mammals, in thelung tissue of mouse and spleen and thymus of humanand ... Activation of STAT1 induces the transcription factor, T-boxexpressed in T cells (T-bet), which is a master regula-tor of Th1 differentiation [11]. T-bet potentiates theexpression of IFN-c, ... kidney,gill, gut, liver and skin tissue of healthy fish (data notshown). After stimulation of kidney cells with a variety of immunostimulants, the expression of t-bet, stat6and foxp3, together with...