Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
... 2009 The Authors Journal compilation ª 2009 FEBS 4635MINIREVIEW Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular ... whichtransports water bidirectionally between the blood and the brain. Astrocytes secrete water into the perivascularspace via AQP4, thereafter maintaining water homeo-stasis in the brain environment ... vasoconstriction and vasodilation. The thickness of the vSMC layer dif-fers according to the size of the vessels. In the brain, pial arteries invade the brain parenchyma and reduce the width of arterioles, then...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc
... organs,including the brain, is regulated by the VEGF system in combination with other signaling systems such as the angiopoietin–Tie, ephrin–Eph, Delta–Notch sys-tems, and the Wnt pathway.Furthermore, ... VEGF-D, binds and activates thisreceptor, resulting in the proliferation and migrationof lymph ECs and lymphangiogenesis [13]. Angiogenesis in brain diseases Brain strokeStroke is induced through: ... neuronprotective in vivo, and may be a therapeutic targetfor diseases involving the degeneration of motorneurons.VEGF-A also binds and activates VEGFR-1, and socould be another candidate for the treatment...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx
... reinter-preted in the context of angiogenesis in the brain. Is itpossible that some of the acute neurovascular events in the brain after stroke represent an endogenous attemptby the brain ... During the delayed phase, brain angiogenesis may pro-vide the critical neurovascular substrates for neuronal remodeling. In thisminireview, we propose the hypothesis that the biphasic nature ... MINIREVIEW Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recoveryafter strokeKen Arai, Guang Jin, Deepti Navaratna and Eng H....
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Tài liệu Báo cáo khoa học: Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions – contribution and expression from motor neurons doc
... protein reached a plateau in the spinal cord about10 days after birth (Fig. 5E).To determine the origin of AChE in the spinalcord, the lumbar region of the spinal cord wassectioned and stained ... showing the lumbar region of the spinal cord (left). The dorsal horn and ventral horn are indicated. The right panelshows PRiMA staining in the lumbar region on the same scale at low magnification. ... overlapping of PRiMAstaining with presynaptic molecules indicates thatPRiMA at NMJs is mainly provided by motorneurons.Innervation regulates the expression ofPRiMA-linked G4AChE in the spinal...
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Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
... coiled-coil domain in the N-termi-nus and a fibrinogen-like domain in the C-terminus.Angiopoietins have a signal sequence in the N-termi-nus for protein secretion, and secreted angiopoietinfunctions ... signalsequence in the N-terminus and ANGPTL6 ⁄ AGFprotein is detected in the circulation, indicating thatit is secreted [9,13]. ANGPTL6 ⁄ AGF induces angio-genesis and arteriogenesis through activation ... findings suggest thatANGPTL6 ⁄ AGF in the circulation counteracts obesity and related insulin resistance by increasing systemicenergy expenditure.A recent study indicates that circulating levels ofhuman...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... com-posed of an extracellular ligand-binding domain, atransmembrane domain and an intracellular tyrosinekinase domain. The binding of a ligand to the extracel-lular domain of the EGFR induces receptor ... dimeriza-tion, activation of the intracellular kinase domain and autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptor. The tyrosine-phosphorylated motifs of the EGFR recruit ... results, in turn, in the inactivation of pro-apoptotic Bcl-2proteins (e.g. PUMA, Bax, Bim and Bad),Fas, and CDK inhibitors (e.g. p27KIP1,p21WAF1 and p15INK4b), and also in the activation...
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Tài liệu Báo cáo khoa học: Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry pptx
... proteins canprovide clues about their roles in the pathogenesis ofCRC. In general, factors that contribute to the patho-genesis of CRC include the accumulation of mutations and the deregulation ... platform.To better understand the roles of these identifiedproteins, they were grouped and analyzed according totheir possible pathogenic roles. The clustering and molecular functions of the ... and S100A9. Figure 3B shows the molecular function categorization of the proteins iden-tified in CRC patients. Regarding major molecular functions, the proteins were mostly associated withbinding...
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Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx
... N-terminalhexahistidine tag was obtained by PCR using the pET21a ⁄ PNT-H6plasmid [30] as the template. The forwardprimer (5¢-TACCGTTAACATCGATATGCATCATCATCATCATCATGC-3¢) was designed to insert a ClaI ... protein involved in the coordination of cell wallsynthesis and cell growth [18], the nucleoprotein and phosphoprotein from measles and Sendai viruses[19,20] and the Rhabdoviridae phosphoprotein ... performed in triplicate. Denaturation ⁄ renaturationspectra were obtained measuring the CD signal at a fixedwavelength (195 nm) when progressively heating from 20 to100 °C, and then recooling to...
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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx
... conformations. At a protein concentration of5 lm, the monomeric species appears to predominate in the case of Y74W*. The gel filtration results indicatethat the Y74W* mutant is dimeric at a concentration ... 3-phosphate. Enzyme activity was determined bymonitoring the decrease in absorbance of NADH at 340 nm. The dependence of the initial rate on the substrateconcentration was analyzed according to the ... reduction in residuevolume at position 74 at the dimer interface created acavity, with consequent destabilization. Formation of the cavity and its consequences were further tested byintroducing the...
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Tài liệu Báo cáo khoa học: Catabolite repression in Escherichia coli – a comparison of modelling approaches docx
... and mathe-matical models are combined in an attempt to obtaininformation on the dynamics and regulatory structuresof the systems. However, depending on the degree ofbiological knowledge and ... modules. The pathways for the individual carbohydrates, including the descriptionof protein synthesis, are connected to the glycolysismodule. The PTS reactions, the synthesis of cAMP and the activation ... do-mains being part of the phosphorylation chain and the EIIC domain representing the membrane domain. Asall components of the PTS, depending on their phos-phorylation status, can interact with...
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