Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
... endosomal membranes pos-sess an E3 ubiquitin ligase that can be released into the cytoplasm by proteolysis. The PA-TM -RING pro-tein RNF13 is synthesized as an integral endosomal membrane protein, ... Incorporation of the RING domain into an integral membrane protein allows the E3 activity to be spatially regulated. Presumably, the TM anchorenables the enzymatic RING domain to be targeted to the same ... deter-mine whether proteolysis is a positive or negativeregulator of RNF13 E3 activity.In addition to PA-TM -RING proteins, only oneother family of mammalian integral membrane RING E3 ubiquitin ligases...
- 18
- 483
- 0
Tài liệu Báo cáo khoa học: The unique sites in SulA protein preferentially cleaved by ATP-dependent Lon protease from Escherichia coli ppt
... regulatory mechanism of SulAmight a lso e xist in other e nterobacteria. It is a lso an interesting issue to see whether such a mechanism exists inother proteolytic regulatory systems, such as the ... appeared to be relatively preferred at the P1sites. On the other hand, the cleavage in the absence ofATP was very much slower, especially in the centralregion, than in the presence of A TP. The ... siteswould lead to rapid inactivation of the protein. As for the C-terminal region, it is interesting to note that the C-terminal 20 residues were suggested to be importantfor the recognition by Lon...
- 7
- 358
- 0
Tài liệu Báo cáo khoa học: The tandemly repeated domains of a b-propeller phytase act synergistically to increase catalytic efficiency doc
... they can increase the amount of available phosphate by interacting together. Additionally,fusing PhyH-DI to a single -domain phytase appears to be an efficient way to improve the activity of the ... greater than the activity sum of PhyH-DI andPhyH-DII and two times greater than that of PhyH-DII. This large variance cannot be ascribed to the function of PhyH-DI alone. The dual -domain phytasewas ... catalytic constants towardsInsP6than the original enzymes. It appears that the action of PhyH-DI is general, i.e. not limited to itsinteraction with PhyH-DII, and can therefore enhance the catalytic...
- 9
- 801
- 0
Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... confersresistance to the bacterial pathogen P. syringae pvtomato carrying the avirulence effector proteins AvrPtoor AvrPtoB [17,18]. The OXI1 protein kinase was also shown to be an upstream regulator ... blot analysis using an anti-HIS or an anti-GSTIgG. Figure 1C shows HIS-PTI1-4 and HIS-OXI1bound to GST-OXI1 and GST-PTI1-4, respectively,but not to GST alone. The kinase-deficient mutant,OXI1K45R, ... for the indicatedtime points. The mixes were then incubated with [c-32P]-ATP andMBP (10 l g) for 30 min. The top panel shows the kinase assayvisualized by autoradiography and the bottom panel...
- 11
- 700
- 0
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... the cell cycle (Fig. 1). Cyclins B1 and B2 appear in S phaseand accumulate in G2and mitosis before disappearingat the transition from metaphase to anaphase. Synthe-sis is controlled at the ... Mo¨ssner J, Mantovani R & Engeland K (2003)Cyclin B1 transcription is enhanced by the p300 coacti-vator and regulated during the cell cycle by aCHR-dependent repression mechanism. FEBS Lett ... is which protein regula-tors bind to this tandem site. E2F proteins were impli-cated early on to regulate through the CDE. Analysisand identification of factors regulating through the CHR is...
- 17
- 876
- 0
Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependentand mediated by the caspase-3-dependent apoptoticpathwayYuanyuan Xiao, Taichang Yuan, Wenqi ... However,owing to the remarkable ability of adipocytes to resistapoptosis, adipocyte apoptosis is much less studied and is poorly understood. Recently, evidence from severalin vivo and in vitro ... 6B–D).Discussion The function of PPARc in adipogenesis is well estab-lished [19]. However, in many other types of cell, the activation of PPARc is linked to the induction ofapoptosis. It has...
- 10
- 594
- 0
Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
... Maintaining the balancebetween cell survival and apoptosis is critical in the maintenance of a healthy organism, and tipping the equilibrium in one or another direction results in eitherKeywordsapoptosis; ... cellsensitivity to apoptotic signals [14,15]. The Bcl-2-homology domain- 3 (BH3)-only protein Bid is an abundant proapoptotic protein of the Bcl-2family that is crucial for death receptor-mediatedapoptosis ... tumournecrosis factor-related apoptosis-inducing ligand(TRAIL)-induced apoptosis, and is necessary for the antiapoptotic response following EGF treatment. Infact, Itch activity is increased by treatment...
- 12
- 718
- 0
Tài liệu Báo cáo khoa học: The plasminogen activator inhibitor 2 transcript is destabilized via a multi-component 3¢ UTR localized adenylate and uridylate-rich instability element in an analogous manner to cytokines and oncogenes pdf
... GM-CSF and IL-8, amongstothers (Fig. 9) [28,29,33], and appear to function viasimilar mechanisms. Of greatest relevance to the PAI-2ARE is the c-fos multidomain class I ARE, for which the structure ... combined andequally seeded into five 35 mm to ensure equal transfectionefficiency within samples and the plates were returned to the incubator for further incubation.In vitro transcription and RNase ... Although there is a significanttranscriptional component to the regulation of PAI-2expression by these agents, in recent years, the role ofpost-transcriptional regulation has come to the forebecause...
- 14
- 635
- 0
Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... appears to be the main nuclear import determinant within the RS domain because the mutant lacking this motif(DRS1) accumulated in the cytoplasm. By contrast,ASF ⁄ SF2 nucleo-cytoplasmic distribution ... activity is encountered by the ability of TIAR to assembleabortive pre-initiation complexes coalescing into cytoplasmic granulescalled stress granules. To elucidate these mechanisms of translationalrepression, ... marked by stars corresponded to proteins identified by MS analysis. Their identity is indicated. The ribosomal proteins present in the TAP purification corresponded to Rpl5, Rpl7A*, Rpl7*, Rpl8,Rpl13,...
- 19
- 666
- 0
Tài liệu Báo cáo khoa học: The two Caenorhabditis elegans metallothioneins (CeMT-1 and CeMT-2) discriminate between essential zinc and toxic cadmium docx
... four-coordinate rather than six-coordinate, or may reflect alarger than normal error in the EXAFS distance due to weaker scattering of the oxygen than of the sulfur,making the Cd–O contribution to the total ... possible to distin-guish between N ⁄ O ⁄ F or between P ⁄ S ⁄ Cl as a scatterer, the difference between O and S is substantial. Therefore,these data suggest that the mechanisms to deal with zincand ... where r is the absorber–scatterer distance in A˚(± 0.02 A˚, inner shell; ± 0.05 A˚, outer shell), N is the number of scatterers around the central atom, 2d2 is the the Debye–Waller factor...
- 12
- 611
- 0
Từ khóa: tài liệu báo cáo nghiên cứu khoa họctài liệu về báo cáo khoa họcbáo cáo khoa học tài chính côngbáo cáo khoa học số loài quý hiếm tại vườn quốc gia ba bểtai lieu bao cao thuc tap khoa co khiNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP