... [K6,8,9]-indolicidin and [K6,8,9,11]-indolicidin bind strongly to DNA in vitro,suggesting inhibition of intracellular functions via inter-ference with DNA ⁄ RNA synthesis. Whether indolicidinuses ... rather than RNA and protein, and that inhibi-tion of DNA synthesis causes E. coli filamentation and contributes to the antimicrobial activity of indolicidin[49]. Unlike indolicidin, [K6,8,9]-indolicidin ... is found near the center of the pore, and the remaining peptides lay close to the edge of the pore, maintaining a parallel orientation with respect to the membrane plane. The resulting pore is...