Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen Christian Roghi1,2, Louise Jones2*, Matthew ... generalmechanism for furin- mediated activation of transmem-brane substrates. The activation of ADAM17 by furin [68] and our observation of an interaction betweenGRASP55 and the ICD of ADAM17 ... 3169 MT1-MMP and furin can interact with GRASP55.Overexpression of GRASP55 has been found toincrease the amount of complex containing MT1-MMP and furin, and the expression of a catalyticallyinactive...
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Tài liệu Báo cáo khoa học: Transient DNA ⁄ RNA-protein interactions docx
... ribosome attains its high level of accuracy in translation, its catalytic triad (rRNA,ribosomal protein, and the peptidyl-tRNA substrate), and the mode of action of many antibiotics, enabling the design ... effort in preparing and analyzing the full-length protein can be extremelyrewarding, as shown by the information obtained with the tumor suppressor protein BRCA2 and its interac-tion with DNA [44,45]. ... structure of human growtharrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen(PCNA) and Aurora A kinase. J Biol Chem 285,22196–22201.9 De Biasio...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... control. The targetmRNA was normalized against actin in the same sample. The PCR primers were as follows: actin forward, 5¢-GAAATCGTGCGTGACATCAAAG-3¢; actin reverse, 5¢-TGTAGTTTCATGGA TGCCACAG-3¢; ... the protein degradation, destabilizing the Akt-1 protein. In addition, the AMP-activated protein kinase pathwaycan affect Akt-1 protein levels in the cell [39].It has been reported that troglitazone ... mitochondrial pathwayBad is one of the prodeath proteins in the Bcl-2 fam-ily, and interacts with prosurvival Bcl-2 family mem-bers to inactivate them [32]. Akt-1 phosphorylates Badat Ser136, inactivating...
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Tài liệu Báo cáo khoa học: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion pptx
... [12,13,17].YpkA-mediated phosphorylation of Gaq impairsguanine nucleotide binding and subsequently inhibitsGaq-mediated signalling pathways including RhoA activation and cytoskeletal rearrangements in the ... Immunoprecipitatedmaterial was analysed by SDS ⁄ PAGE and silver staining, and the large band corresponding to the expected molecular mass of OTUB1 aswell as the area above (rectangle) was excised and digested ... through ingestion and first reach the intestine. The Yersinia surface protein invasin binds to b1 integrins on the apical surface of M cells, which facilitates translocation across the epithelium...
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Tài liệu Báo cáo khoa học: Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide pptx
... TLR contain two major domains: the extracellular ligand-binding domain, characterized byleucine-rich repeats and the intracellular Toll ⁄ IL-1receptor domain (TIR domain) [3]. In mammals, 13TLR ... H& Miyamoto E (1999) Mitogen-activated protein kinase activation and regulation of cyclooxygenase 2expression by platelet-activating factor and hCG in human endometrial adenocarcinoma cell ... Biochemical studies have shownthat RGS proteins have GTPase activity and act as a GTPase activating protein (GAP). As a result, RGSproteins enhance GTP hydrolysis rates for purified Gai and Gaqsubunits...
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Tài liệu Báo cáo khoa học: Plasticity of S2–S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis pdf
... the catalytic dyad(Cys186 and His144) and the residues anchoring the aspartate residue in the P1 position (Arg87, Ala145 and Gln184) which are in the p20 chain. The inhibitors bind the two active ... part by the Georgia State University Molecular Basis of DiseaseProgram, the Georgia Research Alliance, and the Georgia Cancer Coalition. We thank the staff at the SER-CAT beamline at the Advanced ... with the main chain carbonyl and amide of Arg233 in all structures. These hydrogenbonds stabilize and fix the P3 residue in position, inde-pendent of the type of side chain. The side chain of the...
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Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx
... elongated protein of 947 aminoacids and containing a highly hydrophobic domainrich in cysteine [9] (Fig. S1). An extensive search in databases failed to reveal significant homology of the additional ... 1C). The 130 kDa isoform of the K650M mutant was only weakly and variably detected in immunoblots. Scanning densitometry of the gel fur-ther indicated that the intensity of the 105 kDa bandwas ... staining of 293-VnR and ATDC5 cells expressing the Y373C mutant with anti-FGFR3 and anti-phosphotyrosine sera showed bothintracellular and cell-surface phosphotyrosine staining(Figs 2Eb,c and...
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Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
... the nature of the LDL modification;these were quantified at the 96 h time point (Fig. 2D). The extent of protein endocytosis, degradation and intracellular accumulation of apoB was increased in HMDMs ... and glycated apoB in the cells. The rate of removal of the latter species is slow, with only 20–30% of the glycated protein being degraded over a 24 h chase period. In contrast to the rapid and ... thesealdehydes may be substantially greater in the arterywall than in plasma, as a result of cell-mediated forma-tion of these species, with the major route to suchaldehydes being via the intracellular...
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Tài liệu Báo cáo khoa học: Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2 pptx
... specifying cGMP over cAMP as a ligand [12].Taken together the b1–b3 region of the tandem GAFdomain appears to be a major determinant of purineselection. The tandem GAF domain of the AnabaenaAC ... compares the sequences of the cAMP-binding GAF tandem domain of PDE10, the PDEfrom Trypanosoma brucei [15] and cyaB1 and cyaB2ACs with the cGMP-binding tandem GAF domainsfrom mammalian PDEs in ... rPDE2 tandem GAF domains that dis-criminate between the adenine and guanine of cAMP and cGMP as primary ligands.Previous experiments investigating cGMP binding toGAF domains of mammalian PDEs...
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Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc
... Evidence of insulin-stimulatedphosphorylation and activation of the mammaliantarget of rapamycin mediated by a protein kinase Bsignaling pathway. Proc Natl Acad Sci USA 95,7772–7777.12 Nave BT, ... 5¢-CGAGCCAGCAAGACGGATGAG-3¢ (sense) and 5¢-GGCTCTACAAGCTTACTCACTACCCGG-3¢ (antisense) were used, and the amplified productswere normalized by loading an equal amount of extractedRNA for each sample. ... visualized with p-di-methylaminobenzaldehyde reagent, with the plate beingheating at 120 °C for 10 min.StatisticsAll of the data are expressed as the means ± SE. Statisti-cal significance was...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ