Tài liệu Báo cáo khoa học: Exposure of IgG to an acidic environment results in molecular modiﬁcations and in enhanced protective activity in sepsis doc

... pooledhuman IgG to a pH 4 buffer resulted in an increase in its pre-existing binding to antigens present in an Escherichia coli lysate, and in the appearance of somenew bands showing the acquisition of ... compilation ª 2010 FEBS Exposure of IgG to an acidic environment results in molecular modiﬁcations and in enhanced protective activity in sepsis Iglika K. Djoumerska-Alexieva1,*, Jordan D. Dimitrov1,2,3,4,*, ... resulted in a signiﬁcant(P < 0.05) enhancement of immunoreactivity, and in ABCEDFig. 1. Exposure of IgG to a pH 4 buffer results in increased antigen-binding polyreactivity. (A) Densitometric...

Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx

... lipids of thelower leaflet to pack more tightly and extend their acylchains to maintain the integrity of the membrane. Thesubstantial tilt (and resulting disorder) of the top leaf-let lipids and ... ‘tiers’at increasing distance from Ab40. The first and secondtiers contained 20 lipids each, and the third tier con-tained the remaining lipids in the leaflet, between 18 and 24. The results of these ... occur-rence was reported in simulations of melittin [18], and occurs in the present study as well in the case of bothmelittin and Ab40. The lipids of the top leaflet tend to adopt an angle such that they...

Tài liệu Báo cáo khoa học: "Integration of Speech to Computer-Assisted Translation Using Finite-State Automata" pdf

... identical paths in MT and ASRword graphs are increased to 39.7% and 34.4% of the sentences in development and evaluationsets, respectively. The WER of the integratedsystem are 19.0% and 20.7% for ... the results are not promising compared to the results of the rescoring method presented in Table 2 forHMM and IBM translation models. A detailedanalysis revealed that only 31.8% and 26.7% of sentences ... set of experiments to integratethe ASR and MT systems using this method. Weobtain a WER of 19.0% and 20.9% for devel-opment and evaluation sets, respectively. The results are comparable to...

Tài liệu Báo cáo khoa học: Neuropeptide Y-family receptors Y6and Y7in chicken Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region docx

... use-ful for studies of ligand–receptor interactions and 3Dmodeling, and we have previously been able to utilizedifferences between chicken and human Y2 in antagon-ist binding for this purpose ... peptides are involved in a variety of neuronal and endocrine functions, including regula-tion of appetite and circadian rhythm, as well ascardiovascular, reproductive and gastrointestinal func-tions ... segment in a mammalian ancestor.Many of the genes ﬂanking Y6 and Y7on Gga13belong to gene families that have members also on theother two chromosomes that carry Y receptor genes in chicken and...

Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt

... single line scan data obtained with buffer conditions. (A) Representative single line scan graphs obtained at increasing ATPconcentration in the range 0–100 lM and in the presence of 10 nM and ... wereobtained in the presence of 100 lM free Ca2+ and in the presence of 10 nM (B) and 1 lM ATP (C), respectively [scanning rate of 250 Hz,scan scale of 208 nm (y-axis direction in the FSAFM ... Sequential single line scan graphs (which corre-spond to an observation period of  2 s) in the presence of both 1 mM ATP and 100 lM free Ca2+. The broken lines indicate heights of 5.5 nm and 8.0...

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... theadministration of proinflammatory cytokines, leading to a loss of catalytic activity. This downregulation wasat the level of transcription [26]. In the present study,the activity and protein and ... lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, we employed GdCl3 to inactivate KCs basedon the findings of other investigators ... con-centrations of tumor necrosis factor-a and interleukin-6, and increasedhepatic mRNA levels of tumor necrosis factor-a and interleukin-6 weredecreased by depletion of KCs. Our findings suggest...

Tài liệu Báo cáo khoa học: Mechanisms of amyloid ﬁbril formation – focus on domain-swapping doc

... physicochemical and structural studies,cellular and animal models, and clinical studies. In addition to providing a basic understanding of the pro-cesses of protein folding and aggregation, ... principle of domain-swap-ping and how this can underlie the process of amyloid-fibril formation.Cystatins and stefins: an example of domain-swapping proteins forming amyloidsCystatins and stefins ... structurally and functionallyanalogous and those studied so far show evidence of 3D domain-swapping both in vitro and in vivo.Human cystatin C is a member of the cystatin IIfamily of cysteine cathepsin...

Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... line), in the presence of 100 lM neurotoxin (•, dotted line), in thepresence of 200 lM neurotoxin ( , dottedline) and in the presence of neurotoxin and 50 lM dopamine (h, dashed line).Modulation ... a-synuclein(control); lane 2, with 100 lM neurotoxin; lane 3, with 200 lM neu-rotoxin; lane 4, with 100 lM neurotoxin and 50 lM dopamine;lane 5, with 200 lM neurotoxin and 50 lM dopamine. (D) Lane ... neurotoxin; lane 4, with 100 lMneurotoxin and 50 lM dopamine; lane 5, with 200 lM neurotoxin and 50 lM dopamine. Gels were silver stained. (C) Lane M, pre-stained molecular mass markers; lane...

Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx

... the innermembrane by means of the decreasing matrix Picon-centration, which in turn could affect CYPD binding to F0F1-ATP synthase, and decreased binding of theinhibitory protein IF 1 to ... to an insigniﬁcant increase (1.38–1.7%) in the ADP–ATPexchange rate mediated by the ANT in maximallypolarized (forward mode of both ANT and ATPase) and maximally depolarized (reverse mode of ... bycatr and olgm. The activities of ANT and F0F1-ATPsynthase were calculated taking into account the strongirreversible inhibition of ANT and F0F1-ATP synthaseby their respective inhibitors...

Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx

... junctions (6). Injected CagA and peptidoglycan (5), in addition to OipA (1), can trigger NF-jB activation (7) and the release of pro -in ammatory cytokines such as IL-8 (8).These cytokines can alter ... the amount of intracellu-lar CagAPY. Cortactin, ezrin and vinculin are all Srcsubstrates, and Src inactivation causes dephosphoryla-tion of these proteins and is crucial for triggering cellelongation ... number of bacteria gain access to integrins and inject CagA. Thebasal injection model of CagA can also explain whyH. pylori does not cause more gastric damage in infected individuals and may...

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