Tài liệu Báo cáo khoa học: Paradoxical interactions between modifiers and elastase-2 Patricia Schenker and Antonio Baici docx
Tài liệu Báo cáo khoa học: Paradoxical interactions between modifiers and elastase-2 Patricia Schenker and Antonio Baici docx
... Schenker and A. Baici Interactions between modifiers and elastase-2 FEBS Journal 277 (2010) 2486–2495 ª 2010 The Authors Journal compilation ª 2010 FEBS 2495 Paradoxical interactions between modifiers ... interactions between modifiers and elastase-2 Patricia Schenker and Antonio Baici Department of Biochemistry, University of Zurich, SwitzerlandIntroductionThe serine endopeptidase elastase-2 (human leukocyteelastase) ... vTriton X-100; temperature 25 ± 1 °C. The elastase-2 concentration in all assays was8.6 nM.P. Schenker and A. Baici Interactions between modifiers and elastase-2 FEBS Journal 277 (2010) 2486–2495...
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Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
... ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss the possibility that both could func-tion as molecular targets for the prevention and treatment of obesity and metabolic ... focus onthe roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obes-ity and related metabolic diseases, and discuss whetherthese ANGPTLs could be targets for the prevention and treatment of these conditions.Suppression ... ANGPTL2 and ANGPTL6 ⁄ AGF inobesity and related metabolic diseases.The expression of ANGPTL2 and ANGPTL6 ⁄AGF is induced in obese conditions.ANGPTL2 induces chronic adipose tissueinflammation and...
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Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx
... with an inverse broadband probe installed withz-gradient. The 1D spectra1H and 13C; the homonuclear2D spectra DQF-COSY, TOCSY, NOESY and ROESY;the1H–3C HSQC and HMBC; and the1H–15N ... connection between the terminal ac-haOrn1 and theSer2, whereas the other two were for a sequentialconnection between a d-N-hydroxyornithine and ad-N-acetyl-d-N-hydroxyornithine and its reverse, ... assigned1H,13C and 15N chemical shifts are listedin Tables S3–7. The observed NOE contacts and thelong-range1H-13C correlations verified the structure and are listed in listed in Tables S5 and S6....
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Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc
... The distances between the N-terminal amino acids of subunits O and P,subunits O and Q and subunits O and R areshown (B–D). FLIM analysis of theinteraction between cerulean–GAPDH and citrine–GAPDH ... glycolytic and glu-coneogenic pathways, pairs of enzymes – aldolase and glyceraldehyde-3-phosphate dehydrogenase (GAPDH),GAPDH and phosphoglycerate kinase (PGK), GAP-DH and lactate dehydrogenase, and ... 1.0–1.1aThe differences between the two s1values and the two s2values were significant (P < 0.005 for s1 and P < 0.001 for s2).bThedifferences between the two s1values and the two s2values...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
... regulation and mixed lineageleukemia.AcknowledgementsWe thank Imran Hussain, Sahba Kasiri, BishakhaShrestha, Saoni Mandal and other Mandal lab mem-bers for useful discussion and critical ... DNA-binding domain, a ligand-bindingdomain and a transactivation domain. The DNA-bind-ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding domain isresponsible ... trimethylation and H3K36dimethylation during transcription initiation and elongation phases respectively. EFs represent elongation factors.Biochemical functions of MLL K. I. Ansari and S. S. Mandal1800...
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Tài liệu Báo cáo khoa học: Anaerobic sulfatase-maturating enzyme – A mechanistic link with glycyl radical-activating enzymes? docx
... electron transfer and ⁄ or binding and activatingthe peptidyl substrates.Experimental proceduresChemicalsAll chemicals and reagents were obtained from commercialsources and were of analytical ... AdoMet was synthe-sized enzymatically and purified as described previously[17].anSMEcpe and anSMEbt protein expression and purificationProtein expression and purification were performed as pre-viously ... UV-visible absorption spectra of oxidized and dithionite-reduced as purified and reconstituted formsof WT and M1 mutant anSMEbt.Fig. S5. Low field X-band EPR spectra of dithionite-reduced WT...
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Tài liệu Báo cáo khoa học: Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry pptx
... total of eight tumor tissues and eight matched normaltissues were collected from eight CRC patients (TableS1) and protein expression was compared between eachtumor and adjacent normal tissue ... We used solvent extraction and a gel-assisted digestion method, together with isobaric tags with related and absolute quantitation (iTRAQ) reagents to label tumoral and adjacentnormal tissues ... of all eight patients.After comparing protein expression between cancerous and correspondingnormal tissue, we identified 34 upregulated and eight downregulated pro-teins with expression changes...
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Tài liệu Báo cáo khoa học: Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae pptx
... Erg4p, Cbr1p and Ncp1p, which are all involved insterol biosynthesis [25]. We also observed genetic inter-actions between PAKs and ERG4 as well as between PAKs and NCP1. Both ERG4 and NCP1 are ... sterols forcell polarization, and the interactions between PAKs and proteins catalyzing sterol synthesis and storage, itis tempting to speculate that Ste20p and Cla4p mayinfluence sterol homeostasis. ... recombinantSte20p (Fig. 4) indicates that the interaction between Ste20p and the SE synthases Are1p and Are2p isspecific. Binding between Cla4p and Are1p or Are2pwas not observed in a similar set...
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Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins ppt
... structure.Some RRM and KH domains in complex with singlestrand DNA (PDB codes: 2UP1, 1WTB, 1X0F, 1ZZI and 1ZZJ) were also included in the test set because recognitionof single stranded RNA and DNA are ... Fox-1 protein. (B) The intramolecularhydrogen bond between uracil 1 and cytosine 3, and the non-Wat-son–Crick base pair between guanine 2 and adenine 4 for the RNAin complex with Fox-1 protein ... protein–protein [25,28–30] and protein–ligand interactions [30–33]. A few studieshave explored the use of knowledge-based methods forthe prediction of protein–DNA interactions fromstructure...
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Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... membrane and mediate interactions with the cytoskeleton and with signaling molecules. Onthe basis of extensive searches of the human and mousegenomic sequences, it is now known that 18 a-subunits and ... migration and signal transduction. Collectively, N-glycans onadhesion molecules, especially those on E-cadherin and integrins, play keyroles in cell–cell and cell–extracellular matrix interactions, ... fixed and stained with 0.5% crystal violet. Each experiment was performed in triplicate, and three randomly selectedmicroscopic fields within each well were counted. Figure partly reproduced and...
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