Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site speciﬁcities and release of matrikines pptx

... compilation ª 2010 FEBS Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines Andrea Heinz1, Michael C. Jung1, Laurent Duca2, Wolfgang ... solvent-accessi-ble and hence restrict cutting in this area. Cleavage site specificityTo gain a better understanding of the cleavage site specificities of the three MMPs, the active sites weremodeled ... pre-ferred amino acids at the cleavage site positions P1–P4 and P1¢–P4¢ of the substrate and to give a structuralexplanation of the amino acid preferences of MMP-7,MMP-9, and MMP-12, which have...

Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx

... and GST-lofMPK6. However, when lofMPK3 and lofMPK6proteins were tested for phosphorylation with OXI1,no phosphorylation of lofMPK3 or lofMPK6 wasobserved (Fig. 5A). On the other hand, when ... characterized by a conserved DFD amino acidmotif in subdomain VII of the catalytic domain and by the presence of an amino acid insertion of variablesize between subdomains VII and VIII [8,9]. ... response (HR),which is local and rapid cell death at the site of patho-gen infection and limits growth of the micro-organism[2 2–2 4]. Mutants with enhanced disease resistance and exhibiting spontaneous...

Tài liệu Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori docx

... thesurge of 8K-BLP release in this period is reminiscent of the massive release of IGF-I and IGF-II duringpubertal and fetal development, respectively, in mam-mals [4]. Finally, like that of IGFs, ... essential roles in fetal and postnatalgrowth and development of mammals. They are secreted by a wide variety of tissues, with the liver being the major source of circulating IGFs, and regulate cell ... these,bombyxins, a family of peptides produced by the brain of the silkmoth Bombyx mori, were the ﬁrst to be dem-onstrated to have structural homology to vertebrateinsulins [7,8]. Bombyxin-II, one of...

Tài liệu Báo cáo khoa học: Amino acid discrimination by arginyl-tRNA synthetases as revealed by an examination of natural speciﬁcity variants doc

... by aminoacylation and editing? TrendsGenet 12, 60 4–6 10.3 Pauling L (1958) The probability of errors in the pro-cess of synthesis of protein molecules. In FestschriftArthur Stoll, pp. 59 7–6 02. ... misacylation and transla-tional recoding of lysine. Plant J 50, 62 7–6 36.43 Rosenthal GA (1977) The biological effects and mode of action of l-canavanine, a structural analogue of l-arginine. ... challenge faced by plants offers a natural alternative to targeted muta-genesis or rational redesign of the active site of theenzymes to elucidate the mechanism by which ﬁdelity of amino acid...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

... wasfour-fold to ﬁve-fold higher in the presence of 100 and –2 288 –2 152 –2 000 –1 788 –1 260 –3 000 – 234ERE6ERE5ERE4ERE3ERE2ERE1+1 – 234ERE6ERE5ERE4ERE3ERE2ERE1+1Fig. ... ERE2,ERE3 and ERE4 of the HOXC13 promoter. As seenin Fig. 5A, no signiﬁcant binding of actin wasobserved in any of the EREs, irrespective of theabsence and presence of E2. Binding of ERa and ERbwas ... Nuclear extractMLL3 E2 (100 nM) – + – + – + ERαERβFig. 6. (A) Roles of ERa and ERb inE2-dependent recruitment of MLLs (MLL 1– MLL4) into ERE1 and ERE2 of the HOXC13promoter. JAR cells...

Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

... determined at pH 5 and 0.05% SDS, and DO activity at pH 7 and 0.02% SDS.Fig. 3. Dependence of the TH activity of extracts of R3 and thetwo mutant strains on the presence of cofactor,L-dopa. ... independent of the addition of l-dopa cofactor, and the lag period before reachingthe maximal reaction rate without this addition isshort ( 4 0–6 0 s under standard conditions). The THactivity of R3-0337 – extracts ... to be part of the defense sys-tem against wounding and infection by the pathogen[16]. Thus, the timing and location of melanizationseems to be essential for the prevalence of one of thesetwo...

Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc

... Murakami2 and Kenji Aoki21Division of Science of Biological Resources, Graduate School of Science and Technology,2Department of Biofunctional Chemistry,Faculty of Agriculture, Kobe University, ... nm. The cofactor from the puriﬁedenzyme was detected by ﬂuorescence ( F-1050) at anexcitation and emission wavelength of 450 and 530 nm,respectively. Ammonia release was determined by measur-ing ... 2.9 mL of 100 mMsodium/potassium p hosphate buffer ( pH 7.5),0.1 mL of 5 mM4-amino-3-hydroxybenzoic acid, and 0.05 mL of crude extract. The reaction was started by adding 0.1 mL of 4-amino-3-hydroxybenzoate...

Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identiﬁcation of oscillophores ppt

... occur.AcknowledgementsThis work was supported by a grant from Ministry of Science and Technology of the Spanish Government (SAF 200 2–0 2785), INTASgrant (9 7–1 504), and the Netherlands’ Organization for ScientificResearch. ... Netherlands;3Department of Biochemistry and Molecular Biology, Faculty of Chemistry and CeRQT at BarcelonaScientific Parc, University of Barcelona, SpainIn view of the increasing number of reported concentrationoscillations ... sign) of a cycle isthe product of the values (the signs) of its steps. The sign o fthe magnitude of a Ôminus combined autoinfluence path of order pÕ equal those of the arithmetic product of itsÓ...

Tài liệu Báo cáo khoa học: N-Methyl-L-amino acid dehydrogenase from Pseudomonas putida A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily ppt

... curves and gave linear double-reciprocal plotsin the range 1–1 0 mm pyruvate, 5–6 0 mm methyl-amine, and 0.0 5–0 .3 mm NADPH. The families of lines obtained from the double-reciprocal plots of reac-tion ... dehydrogenases and opine dehydrogenases and has no sequence motif char-acteristic of the Rossmann fold, indicating that thestructure of the nicotinamide nucleotide-binding site of NMAADH is completely ... NADPH, and the enzyme in a ﬁnal volume of 1 mL.Cloning and expression of NMAADH in E. coliPCR primers were designed based on the nucleotidesequence of ORF PP3591 located on the 4 080 93 5– 4 081...

Tài liệu Báo cáo khoa học: The lipid ⁄ protein interface as xenobiotic target site Kinetic analysis of tadpole narcosis ppt

... outer and middlerings of transmembrane domains. Curr Opin DrugDiscov Devel 6, 62 0–6 32.20 Miller KW (2002) The nature of sites of general anaes-thetic action. Br J Anaesth 89, 1 7–3 1.21 Sandermann ... Induction of lipid–protein mis-match by xenobiotics with general membrane targets.Biochim Biophys Acta 1150, 13 0–1 33.22 Sandermann H & Pﬂugmacher D (1996) Induction of lipid–protein mismatch by ... binding site (say, of numberj) and denoted by [Pj0] the concentration of macromol-ecules with empty site j. According to the mass-actionlaw, the concentration of molecules with lipid boundto site...

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