Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

... MLL in human malignancies FEBS Journal 277 (2010) 1822–1831 ª 2010 The Author Journal compilation ª 2010 FEBS 1831MINIREVIEW Mixed lineage leukemia: roles in human malignancies and potential therapy Rolf ... proteins. Thus, the MEN1 ⁄ LEDGF-interactingdomain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain, ... 2010)doi:10.1111/j.1742-4658.2010.07608.xThe increasing number of chromosomal rearrangements involving the human MLL gene, in combination with differences in clinical behavior and outcome for MLL-rearranged...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

... thatincludes a DNA-binding domain, a ligand-bindingdomain and a transactivation domain. The DNA-bind-ing domain is responsible for DNA binding speciﬁcity and dimerization, and the ligand-binding ... selective and inde-pendent roles within the hematopoietic system, main-taining quiescence in HSCs and promoting proliferation in progenitors [23]. Similarly, in an independent studyusing a conditional ... domain involved in protein–protein interactions. FYRC and FYRN domains are involved in heterodimerization between MLLN and MLLCterminal fragments. High-mobility group (HMG) domains areinvolved...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human pptx

... Marschalek R (2010) Mixed lineage leukemia: roles in human malignancies and potential therapy. FEBS Jdoi:10.1111/j.1742-4658.2010.07608.x.164 Cosgrove MS & Patel A (2010) Mixed lineage leuke-mia: ... recent clinical trials in epigenetic therapy. Rev Recent Clin Trials 1, 169–182.162 Ansari KI & Mandal SS (2010) Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNAprocessing. ... histones H3 and H4 with crucial roles in maintain-ing normal cellular functions in eukaryotes rangingfrom yeast to humans (Fig. 1). Here, we discuss his-tone H3 lysine 4 (H3K4) methylation and the...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... domain of the cAMPresponse element-binding (CREB) binding protein(CBP) [23], a peptide from the Win motif of MLL1bound to the WD40 repeat protein, WDR5 [24,25] and the C-terminal SET domain in ... requiredfor the structural integrity of the protein, as mutation ofany of the cysteine residues involved in zinc coordina-tion results in protein unfolding [22]. The structure con-tains a positively ... complexes.Binding of the MLL1 Win motif to the central argi-nine-binding pocket of WDR5 raises questions aboutthe proposed role of WDR5 in binding histone H3, atleast while WDR5 is incorporated into...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

... binding proﬁles in a time-dependentmanner in ERE1 and ERE2 (Fig. 5B). In agreementwith the above ﬁndings, binding of ERa and ERb wasincreased in both ERE1 and ERE2 in the presence ofE2. Interestingly, ... Binding of ERa and ERbwas increased in both ERE1 and ERE2 of theHOXC13 promoter (Fig. 5A, lanes 1–4). The levels ofE2-induced binding of ERa and ERb were higher in ERE2 than in ERE1. ERE3 and ... and ERE2. However, in the case ofERb, some constitutive binding was observed in ERE2even in the absence of E2, and this binding wasincreased in the presence of E2 (Fig. 5A,B; compare0 h and...

Tài liệu Báo cáo khoa học: The Mycobacterium tuberculosis membrane protein Rv2560 ) biochemical and functional studies pdf

... proteins that bind to biotinylated cellfractions, including the already characterized adhesionheparin-binding haemagglutinin [27].A B Fig. 5. Saturation curves and critical residues of cell binding. ... show any binding toHepG2 cells or erythrocytes (data not shown).Invasion inhibition assay using HABPsA549 and U937 cell lines were preincubated in thepresence of HABP 11024 in two independent ... protein encoding gene and its transcripts in the M. tuberculosis complex and clinical isolate strains,as well as the characterization of the high-activitybinding peptide (HABP) involved in the...

Tài liệu Báo cáo khoa học: Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica polymerase and silica esterase) doc

... both in thecrystalline state (such as quartz) and in the amorphousstate (such as opal). Silica ⁄ silicate is widely used in industry and medicine for the fabrication of poly(sili-cate), e.g. in ... of silicatein in spicules and in intra- and extracellular vesicles byTEM immunogold labeling. (i) Association ofsilicatein with spicules. (A) Strong antibodyreactions are seen within the axial ... denseaccumulation of gold grains in the extraspicular space,reﬂecting dense packaging of silicatein molecules therealso. The silicatein molecules are arranged around thespicules in concentric rings (Fig. 2B)....

Tài liệu Báo cáo khoa học: "Grammar Error Correction Using Pseudo-Error Sentences and Domain Adaptation" pdf

... mapping features are all binary. The focusingphrase and its two surrounding words of the inputare regarded as the window. The mapping featuresare deﬁned as the pairs of the output phrase and ... were trained using only thereal-error corpus (baseline).• SRC: Trained using only the pseudo-error corpus.• ALL: Trained using the real-error and pseudo-error corpora by simply adding them.• ... ma-chine translation (PBSMT), but there are three dif-ferences; 1) it adopts the conditional random ﬁelds,2) it allows insertion and deletion, and 3) binary and real features are combined....

Tài liệu Báo cáo khoa học: "THE EFFEC TO FEST ABLISHING COHERENCE ELLIPSIS AND ANAPHORA RESOLUTION" pdf

... structure and binding relations are maintained. Reconstructing this representation requires syntac- tic parallelism (ruling out passive/active and nomi- nalization cases) and can result in violation ... (the use of and in exam- ple 2)) 11, thereby identifying the first clause as a unit for coherence establishment and invoking inte- gration of its propositional representation into the discourse ... lawyer 1 theme: Bill ] . After creating a parallel event representation, fill- ing in role fillers present in the target clause, and retrieving remaining role fillers from the source rep-...

Tài liệu Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides ppt

... enzyme–inhib-itor binding interaction.log KðappÞi¼ log KÃþ 1: 18ZEZLﬃﬃIpð7ÞDiscussion In this study we have determined that neomycin B and its close structural analog, neamine, are mixed- typenoncompetitive ... manifes-ted in Figs 3 and 4. Note that the Lineweaver–Burkplot in Fig. 4 is distinctly nonlinear.The results are illustrated in Fig. 5, in which thewhite (open) symbols represent data points taken intothe ... 5 and 1 : 11. This again suggests thatthe inhibitors bind to the enzyme either at two distinctbinding sites, or at the same site but in two differentorientations. For neomycin B, the principal...

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