... 158 5–1 596 ª 2010 The Authors Journal compilation ª 2010 FEBS
REVIEW ARTICLE
Upregulation of the a-secretase ADAM10 – risk or reason
for hope?
Kristina Endres and Falk Fahrenholz
Department of ... intervention within the biosynthetic
pathway of ADAM10 is provided by directly interfer-
ing with the expression of the gene for ADAM10: the
promoter...
... glioma
has important implications for the development of
novel glioma therapies.
Tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL), a member of the tumor necrosis factor
superfamily, ... with tremendous therapeutic potential [9].
The correct functioning of the ubiquitin–proteasome
pathway is essential for the degradation of the major-
ity of intracellul...
... as the ATP-unbound and Ca
2+
-bound
E1Ca
2+
form. In the histogram (Fig. 2A) of the dis-
tribution of the height of the projection of the embed-
ded molecule above the flat membrane surface, the
average ... elevated conformation being independent
of ATP concentration and the average lifetime was in
the order of ms (Figure 3B,C). Therefore, we propose
that SERCA...
... minireview. The work of S.W. was
supported by the Deutsche Forschungsgemeinschaft
(We2843 ⁄ 2-1) and BGAG-Stiftung Walter Hesselbach.
The work of S.B. is supported by grants from the Deut-
sche Forschungsgemeinschaft ... (2011) 119 0–1 202 ª 2011 The Authors Journal compilation ª 2011 FEBS
VirB5 then forms a complex with VirB2, which is a
key step in the formation of the...
... 2–3 and 4–
5). Notably, JSP1 seemed to stimulate preferentially
the phosphorylation of the p46 isoform of JNK,
whereas sorbitol treatment induced phosphorylation of
both the p46 and p55 isoforms. ... necessary for the
intrinsic phosphatase activity of the enzyme. However,
myristoylation determined the subcellular localization
of JSP1, and was required for JSP1-i...
... develop-
ment. Indeed, HSF4 is crucial for development of the
lens and maintenance of the olfactory epithelium [102].
The first evidence for a developmental function of
HSF4 was provided by population ... development, the
trimeric form of HSF4 increases, while the levels of
HSF1 and HSF2 are reduced [102]. In the olfactory
epithelium of 3–6 -week-old mice, the e...
... investigate
the biological importance of these proteins, the Center
for Eukaryotic Structural Genomics (CESG) at the
University of Madison-Wisconsin has established plat-
forms for protein structure ... 000
torsion-angle dynamics time steps per conformer was
performed during the cyana structure calculations. In the
final cycle of the cyana protocol, 100 conformers were
ge...
... summary,
MDL1 forms a homodimeric complex independent of
its subcellular targeting.
The ATPase activity of ABC half-transporters is
critically dependent on the complex formation. We
therefore compared the ... and -11
relative to the cleavage site. The leader sequence inter-
acts with the TOM receptor, responsible for the trans-
location of the preproteins to the tran...
... analy-
ses of Olvas–GFP, Nanos–GFP and Tudor–GFP were performed for
the granule (B). Each curve is the mean of 10 independent mea-
surements. The bleached position is indicated by the white circle
(inset). ... in the
nuage for seconds, and that Olvas–GFP in the cytosol
diffuses rather freely. Although the nuage has been
analyzed as an important structure for the form...
... registered. The K
d
values were estimated by fitting the fluorescence data to a
theoretical equation for a 1 : 1 complex. The K
d
determina-
tions for FNR–Fd were performed either in the absence or
presence ... the
distribution of conformations, and thus promoting
the catalytic reaction [54]. Residues C266 and L268
may influence the conformational freedom of the sub-
st...