Tài liệu Báo cáo khoa học: Epidermal growth factor receptor

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res 66, ... Japan Identiﬁcation of epidermal growth factor, epidermal growth factor receptor and ERBB family proteins Epidermal growth factor (EGF) was originally isola...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... MINIREVIEW Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy Isamu Okamoto Department of Medical Oncology, Kinki University School of Medicine, ... sensitivity to therapy with mAb to epidermal growth factor receptor in colorectal cancer Cetuximab is a chimeric mouse–human mAb that tar- gets the extracell...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-binding domain is responsible for DNA binding speciﬁcity and dimerization, and the ligand-binding ... selective and independent roles within the hematopoietic system, main- taining quiescence in HSCs and promoting proliferation in progenitors [23]. Similarly, in an independent study usi...

Ngày tải lên : 16/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Human intrinsic factor expressed in the plant Arabidopsis thaliana doc

... cobalamin; intrinsic factor; recom- binant. Vitamin B 12 (cobalamin, Cbl) is the most complex of the vitamins [1]; it is a complicated system with three trans- porting proteins and several receptors ... IF. Binding of IF to cubilin Speciﬁc binding of IF–Cbl complex to the immobilized receptor cubilin was conducted on a BIAcore 2000 equipment as described earlier [24]. In short, recom...

Ngày tải lên : 21/02/2014, 00:20

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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx

... listed in Table 1, we blocked EGFR signaling with geﬁtinib. Geﬁtinib is an inhibitor of tyrosine kinase that competes with ATP for binding to the intracellular kinase domain, preventing receptor ... diseases. In severe cases, aberrant growth factor signaling may even give rise to tumors. Among these pathways, epidermal growth Keywords epidermal growth factor receptor;...

Ngày tải lên : 07/03/2014, 00:20

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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): a unique metalloprotein ppt

Ngày tải lên : 16/02/2014, 15:20

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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): structure–function relationships docx

... domain–domain interactions. Abbreviations AD, Alzheimer’s disease; DTNB, 5,5¢-dithiobis-(1-nitrobenzoic acid); GIF, neuronal growth- inhibitory factor; hGIF, human neuronal growth- inhibitory factor; ... a-domain is not directly involved in neuronal growth- inhibitory activity [5,6,17,18]. However, it has been well documented that the two domains of MT do not work independently, and do...

Ngày tải lên : 16/02/2014, 15:20

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**Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc**

... growth- inhibitory factor (GIF) [1] because of the discovery that it is a factor in brain extract with the ability to inhibit neuronal outgrowth. Moreover, MT3 or GIF was reported to be down-regulated in ... [M(II) 3 - Cys 9 ], including three bridging and six terminal cyste- ines. The C-terminal a-domain (amino acids 31-61) binds four divalent metal ions by 11 deprotonated cyste...

Ngày tải lên : 16/02/2014, 15:20

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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... MINIREVIEW Neuronal growth- inhibitory factor (metallothionein-3): evaluation of the biological function of growth- inhibitory factor in the injured and neurodegenerative brain Claire ... distinct biological properties. In this review, we examine the recent developments regarding the function of neuronal growth- inhibi- tory factor within the brain, particularly in response to...

Ngày tải lên : 16/02/2014, 15:20

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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... con- centrations of tumor necrosis factor- a and interleukin-6, and increased hepatic mRNA levels of tumor necrosis factor- a and interleukin-6 were decreased by depletion of...

Ngày tải lên : 14/02/2014, 18:20

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